Ketamine, a racemic mixture consisting of (S)-and (R)-ketamine, has been in clinical use
since 1970. Although best characterized for its dissociative anesthetic properties, ketamine …

Background: Several models describing the pharmacokinetics of ketamine are published
with differences in model structure and complexity. A systematic review of the literature was …

The major therapeutic end points of general anesthesia include hypnosis, amnesia, and
immobility. There is a complex relationship between general anesthesia, responsiveness …

Pain is a common complaint precipitating emergency department (ED) visit, occurring in
more than half of patient encounters. While opioids are effective for acute pain management …

Ketamine is a general anesthetic with over 50 years of safe administration that is in
increasing use for psychiatric indications. This is evidenced by the recent FDA approval of …

We aimed to develop population pharmacokinetic/pharmacodynamic (PK/PD) models that
can effectively describe ketamine and norketamine PK/PD relationships for Montgomery …

Ketamine is a dissociative anesthetic agent with excellent analgesic properties and a
favorable safety profile. The feasibility and efficacy of various routes of administration have …

ABSTRACT BACKGROUND AND OBJECTIVES: Bone fractures constitute a frequent cause
of emergency care in the pediatric population. Opioid drugs are routinely used for analgesia …

Аннотация Проблема церебропротекции в кардиохирургии актуальна несмотря на все
применяемые методики. Благодаря своим свойствам кетамин может занять нишу в …

RESUMO JUSTIFICATIVA E OBJETIVOS: As fraturas ósseas constituem causa frequente de
atendimento de emergência na população pediátrica. Fármacos opioides são …