Human high-altitude adaptation: forward genetics meets the HIF pathway
AW Bigham, FS Lee - Genes & development, 2014 - genesdev.cshlp.org
Humans have adapted to the chronic hypoxia of high altitude in several locations, and
recent genome-wide studies have indicated a genetic basis. In some populations, genetic …
recent genome-wide studies have indicated a genetic basis. In some populations, genetic …
Measuring high-altitude adaptation
LG Moore - Journal of applied physiology, 2017 - journals.physiology.org
High altitudes (> 8,000 ft or 2,500 m) provide an experiment of nature for measuring
adaptation and the physiological processes involved. Studies conducted over the past~ 25 …
adaptation and the physiological processes involved. Studies conducted over the past~ 25 …
Paleoindian settlement of the high-altitude Peruvian Andes
Study of human adaptation to extreme environments is important for understanding our
cultural and genetic capacity for survival. The Pucuncho Basin in the southern Peruvian …
cultural and genetic capacity for survival. The Pucuncho Basin in the southern Peruvian …
The increase in hemoglobin concentration with altitude varies among human populations
M Gassmann, H Mairbäurl, L Livshits… - Annals of the New …, 2019 - Wiley Online Library
Decreased oxygen availability at high altitude requires physiological adjustments allowing
for adequate tissue oxygenation. One such mechanism is a slow increase in the hemoglobin …
for adequate tissue oxygenation. One such mechanism is a slow increase in the hemoglobin …
Evolutionary genomic dynamics of Peruvians before, during, and after the Inca Empire
Native Americans from the Amazon, Andes, and coastal geographic regions of South
America have a rich cultural heritage but are genetically understudied, therefore leading to …
America have a rich cultural heritage but are genetically understudied, therefore leading to …
Human genetic adaptation to high altitude: evidence from the Andes
Whether Andean populations are genetically adapted to high altitudes has long been of
interest. Initial studies focused on physiological changes in the O2 transport system that …
interest. Initial studies focused on physiological changes in the O2 transport system that …
Hypoxia-induced signaling in the cardiovascular system: pathogenesis and therapeutic targets
Hypoxia, characterized by reduced oxygen concentration, is a significant stressor that affects
the survival of aerobic species and plays a prominent role in cardiovascular diseases. From …
the survival of aerobic species and plays a prominent role in cardiovascular diseases. From …
Natural selection on genes related to cardiovascular health in high-altitude adapted Andeans
The increase in red blood cell mass (polycythemia) due to the reduced oxygen availability
(hypoxia) of residence at high altitude or other conditions is generally thought to be …
(hypoxia) of residence at high altitude or other conditions is generally thought to be …
Pathophysiology and treatment of high-altitude pulmonary vascular disease
It is estimated that> 140 million people live above 2500 m in various regions of the world. 1
There are many challenges to living at high altitude, but chronic exposure to alveolar …
There are many challenges to living at high altitude, but chronic exposure to alveolar …
Widespread signals of convergent adaptation to high altitude in Asia and America
Living at high altitude is one of the most difficult challenges that humans had to cope with
during their evolution. Whereas several genomic studies have revealed some of the genetic …
during their evolution. Whereas several genomic studies have revealed some of the genetic …