Sepsis and the heart

MW Merx, C Weber - Circulation, 2007 - Am Heart Assoc
Sepsis is generally viewed as a disease aggravated by an inappropriate immune response
encountered in the afflicted individual. As an important organ system frequently …

[PDF][PDF] NF-kappaB action in sepsis: the innate immune system and the heart

MA Brown, WK Jones - Front Biosci, 2004 - article.imrpress.com
[Frontiers in Bioscience 9, 1201-1217, May 1, 2004] 1201 NF-κB ACTION IN SEPSIS: THE
INNATE IMMUNE SYSTEM AND THE HEART Maria A Page 1 [Frontiers in Bioscience 9 …

Peroxisome proliferator activator receptor-γ ligands, 15-deoxy-Δ12, 14-prostaglandin J2 and ciglitazone, reduce systemic inflammation in polymicrobial sepsis by …

B Zingarelli, M Sheehan, PW Hake… - The Journal of …, 2003 - journals.aai.org
Peroxisome proliferator activator receptor-γ (PPARγ) is a nuclear receptor that controls the
expression of several genes involved in metabolic homeostasis. We investigated the role of …

Anti-inflammatory effect of Ruta graveolens L. in murine macrophage cells

SK Raghav, B Gupta, C Agrawal, K Goswami… - Journal of …, 2006 - Elsevier
Ruta graveolens L.(Rutaceae) is used for several therapeutic purposes worldwide. The
present study is designed to investigate the effect of plant extract of Ruta graveolens on …

To treat or not to treat: the effects of pain on experimental parameters

NC Peterson, EA Nunamaker… - Comparative …, 2017 - ingentaconnect.com
A common dilemma faced by all animal bioethics committees arises when exceptions are
proposed to the use of analgesics in painful procedures. The committee and researcher …

Inhibition of NLRP3 inflammasome prevents LPS-induced inflammatory hyperalgesia in mice: contribution of NF-κB, caspase-1/11, ASC, NOX, and NOS isoforms

A Dolunay, SP Senol, M Temiz-Resitoglu, DS Guden… - Inflammation, 2017 - Springer
The nucleotide-binding domain and leucine-rich repeat protein 3 (NLRP3), an intracellular
signaling molecule that senses many environmental-and pathogen/host-derived factors, has …

Cardiovascular dysfunction in sepsis at the dawn of emerging mediators

C Sergi, F Shen, DW Lim, W Liu, M Zhang… - Biomedicine & …, 2017 - Elsevier
Subcellular dysfunction and impaired metabolism derived from the complex interaction of
cytokines and mediators with cellular involvement are on the basis of the cardiovascular …

[HTML][HTML] Contribution of iNOS/sGC/PKG pathway, COX-2, CYP4A1, and gp91phox to the protective effect of 5, 14-HEDGE, a 20-HETE mimetic, against vasodilation …

B Tunctan, B Korkmaz, AN Sari, M Kacan, D Unsal… - Nitric Oxide, 2013 - Elsevier
We have previously demonstrated that a stable synthetic analog of 20-
hydroxyeicosatetraenoic acid (20-HETE), N-[20-hydroxyeicosa-5 (Z), 14 (Z)-dienoyl] glycine …

Cyclooxygenase inhibition in sepsis: is there life after death?

DM Aronoff - Mediators of inflammation, 2012 - Wiley Online Library
Prostaglandins are important mediators and modulators of the inflammatory response to
infection. The prostaglandins participate in the pathogenesis of hemodynamic collapse …

[图书][B] Бактериальный эндотоксикоз: взгляд патолога

ВБ Писарев, ВВ Новочадов, НВ Богомолова - 2008 - elibrary.ru
Монография посвящена проблеме острых и хронических эндогенных интоксикаций в
эксперименте и клинике. Она затрагивает проблемы органопатологии и …