Thrombotic thrombocytopenic purpura (TTP; also known as Moschcowitz disease) is
characterized by the concomitant occurrence of often severe thrombocytopenia …

Both neutrophil extracellular traps (NETs) and von Willebrand factor (VWF) are essential for
thrombosis and inflammation. During these processes, a complex series of events, including …

Objectives To develop evidence-based recommendations for clinicians caring for children
(including infants, school-aged children, and adolescents) with septic shock and other …

Ischemic stroke is caused by a thromboembolic occlusion of cerebral arteries. Treatment is
focused on fast and efficient removal of the occluding thrombus, either via intravenous …

Coronavirus disease of 2019 (COVID-19) is the clinical manifestation of the respiratory
infection caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). While …

Abstract von Willebrand factor (VWF) is a large adhesive glycoprotein with established
functions in hemostasis. It serves as a carrier for factor VIII and acts as a vascular damage …

Background Consistent with fulminant endothelial cell activation, elevated plasma von
Willebrand factor (VWF) antigen levels have been reported in patients with COVID‐19. The …

Following vascular injury, blood loss is controlled by the mechanisms of hemostasis. During
this process, the serine proteinase, thrombin, is generated both locally and rapidly at sites of …

Introduction: Activation of the hemostatic system can occur in many clinical conditions.
However, a systemic and strong activation of coagulation complicating clinical settings such …

Following initiation of coagulation as part of the hemostatic response to injury, thrombin is
generated from its inactive precursor prothrombin by factor Xa as part of the prothrombinase …