Inflammation and immune dysfunction in Parkinson disease

MG Tansey, RL Wallings, MC Houser… - Nature Reviews …, 2022 - nature.com
Parkinson disease (PD) is a progressive neurodegenerative disease that affects peripheral
organs as well as the central nervous system and involves a fundamental role of …

[HTML][HTML] Amyloid β, Tau, and α-Synuclein aggregates in the pathogenesis, prognosis, and therapeutics for neurodegenerative diseases

U Sengupta, R Kayed - Progress in neurobiology, 2022 - Elsevier
Aggregation of specific proteins are histopathological hallmarks of several
neurodegenerative diseases, such as, Amyloid β (Aβ) plaques and tau neurofibrillary …

The pathogenesis of Parkinson's disease: a complex interplay between astrocytes, microglia, and T lymphocytes?

AN MacMahon Copas, SF McComish… - Frontiers in …, 2021 - frontiersin.org
Parkinson's disease (PD), the second most common neurodegenerative disease, is
characterised by the motor symptoms of bradykinesia, rigidity and resting tremor and non …

Mitochondrial dysfunction, protein misfolding and neuroinflammation in Parkinson's disease: roads to biomarker discovery

A Picca, F Guerra, R Calvani, R Romano… - Biomolecules, 2021 - mdpi.com
Parkinson's Disease (PD) is a highly prevalent neurodegenerative disease among older
adults. PD neuropathology is marked by the progressive loss of the dopaminergic neurons …

Gut microenvironmental changes as a potential trigger in Parkinson's disease through the gut–brain axis

SJ Chen, CH Lin - Journal of biomedical science, 2022 - Springer
Parkinson's disease (PD) is the second most common neurodegenerative disease attributed
to the synergistic effects of genetic risk and environmental stimuli. Although PD is …

TGF-β1 mediates hypoxia-preconditioned olfactory mucosa mesenchymal stem cells improved neural functional recovery in Parkinson's disease models and patients

Y Zhuo, WS Li, W Lu, X Li, LT Ge, Y Huang… - Military Medical …, 2024 - Springer
Background Parkinson's disease (PD) is a neurodegenerative disorder characterized by the
degeneration of dopaminergic neurons in the substantia nigra (SN). Activation of the …

Th17 cells and inflammation in neurological disorders: Possible mechanisms of action

Y Shi, B Wei, L Li, B Wang, M Sun - Frontiers in immunology, 2022 - frontiersin.org
Neurological disorders (NDs) are one of the leading causes of global death. A sustained
neuroinflammatory response has been reported to be associated with the pathogenesis of …

Alpha synuclein: neurodegeneration and inflammation

G Forloni - International journal of molecular sciences, 2023 - mdpi.com
Alpha-Synuclein (α-Syn) is one of the most important molecules involved in the
pathogenesis of Parkinson's disease and related disorders, synucleinopathies, but also in …

The role of NURR1 in metabolic abnormalities of Parkinson's disease

M Al-Nusaif, Y Yang, S Li, C Cheng, W Le - Molecular neurodegeneration, 2022 - Springer
A constant metabolism and energy supply are crucial to all organs, particularly the brain.
Age-dependent neurodegenerative diseases, such as Parkinson's disease (PD), are …

Long-term hyperglycemia aggravates α-synuclein aggregation and dopaminergic neuronal loss in a Parkinson's disease mouse model

YQ Lv, L Yuan, Y Sun, HW Dou, JH Su, ZP Hou… - Translational …, 2022 - Springer
Background Growing evidence suggests an association between Parkinson's disease (PD)
and diabetes mellitus (DM). At the cellular level, long-term elevated levels of glucose have …