Pathogenicity and virulence of the liver flukes Fasciola hepatica and Fasciola Gigantica that cause the zoonosis Fasciolosis

R Lalor, K Cwiklinski, NED Calvani, A Dorey, S Hamon… - Virulence, 2021 - Taylor & Francis
Fasciolosis caused by the liver flukes Fasciola hepatica and Fasciola gigantica is one of the
most important neglected parasitic diseases of humans and animals. The ability of the …

Current threat of triclabendazole resistance in Fasciola hepatica

JM Kelley, TP Elliott, T Beddoe, G Anderson… - Trends in …, 2016 - cell.com
Triclabendazole (TCBZ) is the only chemical that kills early immature and adult Fasciola
hepatica (liver fluke) but widespread resistance to the drug greatly compromises fluke …

Fasciola and fasciolosis in ruminants in Europe: Identifying research needs

NJ Beesley, C Caminade, J Charlier… - Transboundary and …, 2018 - Wiley Online Library
Fasciola hepatica is a trematode parasite with a global distribution, which is responsible for
considerable disease and production losses in a range of food producing species. It is also …

A prospective view of animal and human Fasciolosis

K Cwiklinski, SM O'neill, S Donnelly… - Parasite …, 2016 - Wiley Online Library
Fasciolosis, a food‐borne trematodiasis, results following infection with the parasites,
Fasciola hepatica and Fasciola gigantica. These trematodes greatly affect the global …

[HTML][HTML] Refugia and anthelmintic resistance: concepts and challenges

JE Hodgkinson, RM Kaplan, F Kenyon… - International Journal for …, 2019 - Elsevier
Anthelmintic resistance is a threat to global food security. In order to alleviate the selection
pressure for resistance and maintain drug efficacy, management strategies increasingly aim …

[HTML][HTML] Recent advances in candidate-gene and whole-genome approaches to the discovery of anthelmintic resistance markers and the description of drug/receptor …

AC Kotze, PW Hunt, P Skuce… - International Journal for …, 2014 - Elsevier
Anthelmintic resistance has a great impact on livestock production systems worldwide, is an
emerging concern in companion animal medicine, and represents a threat to our ongoing …

[HTML][HTML] Epidemiology and impact of Fasciola hepatica exposure in high-yielding dairy herds

A Howell, M Baylis, R Smith, G Pinchbeck… - Preventive veterinary …, 2015 - Elsevier
The liver fluke Fasciola hepatica is a trematode parasite with a worldwide distribution and is
the cause of important production losses in the dairy industry. The aim of this observational …

A major locus confers triclabendazole resistance in Fasciola hepatica and shows dominant inheritance

NJ Beesley, K Cwiklinski, K Allen, RC Hoyle… - PLoS …, 2023 - journals.plos.org
Fasciola hepatica infection is responsible for substantial economic losses in livestock
worldwide and poses a threat to human health in endemic areas. The mainstay of control in …

Understanding the role of wild ruminants in anthelmintic resistance in livestock

TL Brown, PM Airs, S Porter, P Caplat… - Biology …, 2022 - royalsocietypublishing.org
Wild ruminants are susceptible to infection from generalist helminth species, which can also
infect domestic ruminants. A better understanding is required of the conditions under which …

Genome-wide approaches to investigate anthelmintic resistance

SR Doyle, JA Cotton - Trends in parasitology, 2019 - cell.com
The rapid evolution of anthelmintic resistance in a number of parasites of livestock and
domesticated animals has occurred in response to widespread use of anthelmintics for …