The β-ketoester structural motif continues to intrigue chemists with its electrophilic and
nucleophilic sites. Proven to be a valuable tool within organic synthesis, natural product, and …

Catalytic deracemization of α-branched aldehydes is a direct strategy to construct
enantiopure α-tertiary carbonyls, which are essential to pharmaceutical applications. Here …

The recent emergence of biological activities of chiral 3-substituted-3-hydroxy-2-oxindoles
has inspired synthetic chemists to develop new methodologies for their synthesis. Both …

Reactions that form a product with the same reactive functionality as that of one of the
starting compounds frequently end in oligomerization. As a salient example, selective aldol …

The preparation through Robinson annulation of enantiopure building blocks with both
academic and industrial relevance, such as the Wieland–Miescher and Hajos–Parrish …

An efficient asymmetric total synthesis of (S)-baclofen was accomplished via a one-pot
operation from commercially available materials using sequential reactions, such as aldol …

Mixing of acryloylchloride, dienone 2, N, N-diisopropylethylamine with chiral organocatalyst
5a, which could simultaneously act as Brønsted and Lewis base catalysts, led to a one-pot …

A new bifunctional catalyst containing a silanol group has been designed and synthesized
with high enantioselectivity in three steps. The hydrogen-bonding properties of this …

Simple primary–tertiary diamines easily derived from natural primary amino acids have been
used to catalyze the aldol reactions in water. The 1 mol% of diamine catalyst is sufficient to …

A new type of diarylprolinol-based catalyst, which contains a dioctylamino group in the
presence of a newly developed ionic liquid supported (ILS) benzoic acid as cocatalyst, is …