Brain-derived neurotrophic factor (BDNF) is a member of the neurotrophin family of secreted
proteins. Signaling cascades induced by BDNF and its receptor, the receptor tyrosine kinase …

Neurotrophins, such as brain-derived neurotrophic factor (BDNF), are prominent regulators
of neuronal survival, growth and differentiation during development. While trophic factors are …

Cerebral organoids (COs) are rapidly accelerating the rate of translational neuroscience
based on their potential to model complex features of the developing human brain. Several …

The epidermal growth factor receptor (EGFR) is the prototypical member of a family of
membrane-associated intrinsic tyrosine kinase receptors, the ErbB family. EGFR is activated …

Epidermal growth factor receptor (EGFR) is reportedly overexpressed in most esophageal
squamous cell carcinoma (ESCC) patients, but anti-EGFR treatments offer limited survival …

Multiple non-animal-based test methods have never been formally validated. In order to use
such new approach methods (NAMs) in a regulatory context, criteria to define their …

Astrocytes are increasingly recognised as partaking in complex homeostatic mechanisms
critical for regulating neuronal plasticity following central nervous system (CNS) insults …

Brain derived neurotrophic factor (BDNF) is well recognized for its neuroprotective functions,
via activation of its high affinity receptor, tropomysin related kinase B (TrkB). In addition …

Dendritic spines are tiny membrane specialization forming the postsynaptic part of most
excitatory synapses. They have been suggested to play a crucial role in regulating synaptic …

The nerve growth factor family of growth factors, collectively known as neurotrophins, are
evolutionarily ancient regulators with an enormous range of biological functions. Reflecting …