Objectives One of the most frequent cerebral lesions in mitochondrial disorders (MIDs) on
imaging is the stroke-like lesion (SLL) clinically manifesting as stroke-like episode (SLE …

Mitochondria is a unique cellular organelle involved in multiple cellular processes and is
critical for maintaining cellular homeostasis. This semi-autonomous organelle contains its …

Background and Objectives Low buffy coat mitochondrial DNA copy number (mtDNA-CN) is
associated with incident risk of stroke and poststroke mortality; however, its prognostic utility …

Mitochondrial stroke-like episodes (SLEs) are a hallmark of mitochondrial
encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS). They should be …

Polymerase γ catalytic subunit (POLG), a nuclear gene, encodes the enzyme responsible for
mitochondrial DNA (mtDNA) replication. POLG mutations are a major cause of inherited …

Background and study aims There are limited data regarding indeterminate acute liver
failure (ALF). The study aims to perform a post hoc analysis using genetic methods for the …

The association of cerebellar ataxia and hypogonadism occurs in a heterogeneous group of
disorders, caused by different genetic mutations often associated with a recessive …

The correct functioning of mitochondria is essential for the balance and normal activity of the
cell. Mutations in the genome of this organelle lead to the development of various severe …

Mitochondria is an integral part of the cell, plays a crucial role in the regulation of energy
metabolisms, cell differentiation, signaling, and cell death. Mitochondrial dysfunction leads …