Epithelial-mesenchymal transition (EMT) is a cellular biological process involved in
migration of primary cancer cells to secondary sites facilitating metastasis. Besides, EMT …

Metastasis is a pivotal event that accelerates the prognosis of cancer patients towards
mortality. Therapies that aim to induce cell death in metastatic cells require a more detailed …

Intratumoral heterogeneity is a major ongoing challenge in the effective therapeutic targeting
of cancer. Accumulating evidence suggests that a fraction of cells within a tumor termed …

Elucidating the design principles of regulatory networks driving cellular decision-making has
fundamental implications in mapping and eventually controlling cell-fate decisions. Despite …

The epithelial–mesenchymal transition (EMT) is a process by which cells lose epithelial
traits, such as cell–cell adhesion and apico-basal polarity, and acquire migratory and …

Individual cells within an otherwise genetically homogenous population constantly undergo
fluctuations in their molecular state, giving rise to non-genetic heterogeneity. Such diversity …

Simple Summary Epithelial–mesenchymal transition (EMT) and its reverse process
mesenchymal–epithelial transition (MET) are considered critical events in the cancer …

Cancer is not a hard-wired phenomenon but an evolutionary disease. From the onset of
carcinogenesis, cancer cells continuously adapt and evolve to satiate their ever-growing …

Phenotypic (non-genetic) heterogeneity has significant implications for the development and
evolution of organs, organisms, and populations. Recent observations in multiple cancers …

Despite the fact that different genetic programmes drive metastasis of solid tumours, the
ultimate outcome is the same: tumour cells are empowered to pass a series of physical …