Epigenetic modulators perform critical functions in gene expression for rapid adaption to
external stimuli and are prevalent in all higher-order organisms. The establishment of a link …

Successful mapping of the human genome has sparked a widespread interest in
deciphering functional information encoded in gene sequences. However, because of the …

Oxoglutarate (2OG) oxygenases are validated agrochemical and human drug targets. The
potential for modulating their activity with 2OG derivatives has not been explored, possibly …

Reversible post-translational modifications (PTMs) are key to establishing protein–protein
and protein–nucleic acid interactions that govern a majority of the signaling pathways in …

Cell surface receptors transmit extracellular information into cells. Spatiotemporal regulation
of receptor signaling is crucial for cellular functions, and dysregulation of signaling causes …

In seeding plants, biosynthesis of the phytohormone ethylene, which regulates processes
including fruit ripening and senescence, is catalyzed by 1-aminocyclopropane-1-carboxylic …

Modern developments in organic chemistry, molecular biology, virology, and genetics have
opened new, exciting possibilities to better understand physiology and to create innovative …

Variants of isocitrate dehydrogenase (IDH) 1 and 2 (IDH1/2) alter metabolism in cancer cells
by catalyzing the NADPH-dependent reduction of 2-oxoglutarate (2OG) to (2R) …

Jumonji-C (JmjC) domain-containing protein 5 (JMJD5) is a human 2-oxoglutarate (2OG)
and Fe (II)-dependent oxygenase which catalyses the post-translational C3 hydroxylation of …

Enzymatic methylation at carbon five on cytosine (5mC) in DNA is a hallmark of mammalian
epigenetic programming and is critical to gene regulation during early embryonic …