Uric acid (UA) is the end product of purine nucleotide metabolism in the human body.
Hyperuricemia is an abnormally high level of UA in the blood and may result in arthritis and …

During the last century, there has been an increasing prevalence of hyperuricaemia noted in
many populations. While uric acid is usually discussed in the context of gout …

More than any other cytokine family, the 11 members of the IL-1 family are associated with
innate immune responses, which occur in acute inflammation and chronic inflammatory …

Uric acid is the final product of purine metabolism, and its increased serum levels have been
directly involved in the pathogenesis and natural history of hypertension. The relationship …

Substantial evidence suggests that chronic hyperuricemia is an independent risk factor for
hypertension, metabolic syndrome, chronic kidney disease (CKD) and cardiovascular …

Purine metabolism in the circulatory system yields uric acid as its final oxidation product,
which is believed to be linked to the development of gout and kidney stones. Hyperuricemia …

Objectives The study of the proinflammatory role of uric acid has focused on the effects of its
crystals of monosodium urate (MSU). However, little is known whether uric acid itself can …

Uric acid is the final oxidation product of purine metabolism in circulation and has been
associated with the occurrence of gout and kidney stones. Type 2 diabetes mellitus and …

Uric acid is a product of purine metabolism and has been linked to gout and kidney calculi.
Chronic kidney disease (CKD) and hypertension (HTN) are two major public health …

Accumulating evidence suggests that asymptomatic hyperuricemia contributes to the
comorbidities with which it associates and that proper asymptomatic hyperuricemia …