Important unresolved questions in the management of hepatic encephalopathy: An ISHEN consensus

JS Bajaj, M Lauridsen, EB Tapper… - Official journal of the …, 2020 - journals.lww.com
Management of hepatic encephalopathy (HE) remains challenging from a medical and
psychosocial perspective. Members of the International Society for Hepatic Encephalopathy …

Hepatic encephalopathy: current and emerging treatment modalities

MA Fallahzadeh, RS Rahimi - Clinical Gastroenterology and Hepatology, 2022 - Elsevier
Hepatic encephalopathy (HE) is a potentially reversible neurocognitive complication of
cirrhosis. It has been reported in at least 30% of patients with cirrhosis and imposes a …

AASLD Practice guidance on Acute-on-chronic liver failure and the management of critically Ill patients with cirrhosis

CJ Karvellas, JS Bajaj, PS Kamath, L Napolitano… - Hepatology, 2024 - journals.lww.com
The clinical stages of cirrhosis have traditionally been divided into a compensated phase
with no complications and a decompensated phase that manifests with complications of …

Management of the acute on chronic liver failure in the intensive care unit

CJ Karvellas, T Gustot, J Fernandez - Liver International, 2023 - Wiley Online Library
Acute on chronic liver failure (ACLF) reflects the development of organ failure (s) in a patient
with cirrhosis and is associated with high short‐term mortality. Given that ACLF has many …

Amino acids, ammonia, and hepatic encephalopathy

K Kroupina, C Bémeur, CF Rose - Analytical biochemistry, 2022 - Elsevier
Hepatic encephalopathy (HE) is a decline in brain function arising due to liver insufficiency.
The liver's diminished capacity to clear ammonia, and the subsequent accumulation of it, is …

Active clinical trials in hepatic encephalopathy: something old, something new and something borrowed

T Balzano - Neurochemical Research, 2023 - Springer
Hepatic encephalopathy (HE) is a potentially reversible neurocognitive syndrome that
occurs in patients with acute or chronic liver disease. Currently, most of the therapies for HE …

Hepatic encephalopathy

D Häussinger, RK Dhiman, V Felipo, B Görg… - Nature Reviews …, 2022 - nature.com
Hepatic encephalopathy (HE) is a prognostically relevant neuropsychiatric syndrome that
occurs in the course of acute or chronic liver disease. Besides ascites and variceal bleeding …

Hepatic encephalopathy–recent advances in treatment and diagnosis

S Nardelli, S Gioia, J Faccioli, O Riggio… - Expert Review of …, 2023 - Taylor & Francis
Introduction Hepatic encephalopathy (HE) is a peculiar kind of brain dysfunction typical of
liver cirrhosis characterized by nonspecific neurological and psychiatric manifestations. HE …

P: 9 Pharmacotherapies that Specifically Target Ammonia for the Prevention and Treatment of Hepatic Encephalopathy in Adults With Crrhosis

HD Zacharias, AP Zacharias, LL Gluud… - Official journal of the …, 2019 - journals.lww.com
BACKGROUND: Ammonia plays a key role in the genesis of hepatic encephalopathy (HE).
Recent interest has focused on drugs which specifically target ammonia, eg sodium …

Polyethylene glycol versus lactulose in the treatment of hepatic encephalopathy: a systematic review and meta-analysis

GJ Hoilat, MF Ayas, JN Hoilat… - BMJ Open …, 2021 - bmjopengastro.bmj.com
Background Hepatic encephalopathy (HE) is defined as brain dysfunction that occurs
because of acute liver failure or liver cirrhosis and is associated with significant morbidity …