The control of Leishmania infection relies primarily on chemotherapy till date. Resistance to
pentavalent antimonials, which have been the recommended drugs to treat cutaneous and …

The growing incidence of parasitic resistance against generic pentavalent antimonials,
specifically for visceral disease in Indian subcontinent, is a serious issue in Leishmania …

Nucleic acid sequences containing unmethylated CpG dinucleotides that modulate an
immune response including stimulating a Th1 pattern of immune activation, cytokine …

Abstract Background The trypanosomatids Leishmania major, Trypanosoma brucei and
Trypanosoma cruzi cause some of the most debilitating diseases of humankind: cutaneous …

The present invention shows that DNA vaccine vectors can be improved by removal of CpG-
N motifs and optional addition of CpG-S motifs. In addition, for high and long-lasting levels of …

Protein kinases represent promising drug targets for a number of human and animal
diseases. The recent completion of the sequenced genomes of three human-infective …

Trypanosomes are protozoan agents of major parasitic diseases such as Chagas' disease in
South America and sleeping sickness of humans and nagana disease of cattle in Africa …

The present invention relates to pharmaceutical compositions comprising at least one
fragment of a polynucleotide, preferably at least one antigen, and optionally a …

The reason why Leishmania parasites are susceptible to organic antimonial drugs, the
standard chemotherapeutic agents for over 50 years, apparently lies in the fact that the …

The mammalian form of the protozoan parasite Leishmania mexicana contains high activity
of a cysteine proteinase (LmCPb) encoded on a tandem array of 19 genes (lmcpb) …