An overview of recent studies on the analysis of pharmaceutical polymorphs

N Chieng, T Rades, J Aaltonen - Journal of pharmaceutical and biomedical …, 2011 - Elsevier
Pharmaceutical solids are well known to be able to exist in different solid-state forms and
there are a wide variety of solid-state analytical techniques available to characterize …

Solubility and dissolution enhancement strategies: current understanding and recent trends

S Jain, N Patel, S Lin - Drug development and industrial pharmacy, 2015 - Taylor & Francis
Identification of lead compounds with higher molecular weight and lower aqueous solubility
has become increasingly prevalent with the advent of high throughput screening. Poor …

New insight into improving the solubility of poorly soluble drugs by preventing the formation of their hydrogen-bonds: A case of dapsone salts with camphorsulfonic …

Y Wu, X Hao, J Li, A Guan, Z Zhou, F Guo - CrystEngComm, 2021 - pubs.rsc.org
Improving the solubility of poorly soluble drugs has always been a challenging subject in the
field of medicine. In this regard, a pharmaceutical cocrystal strategy has been considered to …

[引用][C] Strategies to address low drug solubility in discovery and development

HD Williams, NL Trevaskis, SA Charman… - Pharmacological …, 2013 - ASPET

Investigating the Correlation Between Drug Physical Properties and Physical Characteristics and Drug Entrapment Efficiencies of Chitosan-TPP Nanoparticles

A Jaradat, WM Obeidat - Journal of Pharmaceutical Sciences, 2023 - Elsevier
Chitosan nanoparticles (NPs) have been the subject of intensive research. This study aimed
to determine how different drug characteristics such as molecular weights, drug solubility in …

Saturation solubility and dissolution property improvement of albendazole by salt formation approach

M Patel, D Mori, K Dudhat, S Shah, J Chavda… - Journal of …, 2021 - Springer
Purpose Albendazole belongs to BCS-II category whose systemic and local anthelmintic
effectiveness is restricted due to its low water solubility–related dissolution properties. The …

Improved Solubility of Baclofen Using Suitable Coformers

E Pourabdollah, E Rahimpour, A Jouyban… - Journal of Solution …, 2024 - Springer
This work presents the application of L-tartaric acid (L-TA), ascorbic acid (AA), and L-
carnitine (L-CAR) as a safe and non-toxic alternative agent to enhance the aqueous …

Effect of counterions on physicochemical properties of prazosin salts

L Kumar, CL Meena, YB Pawar, B Wahlang, K Tikoo… - AAPS …, 2013 - Springer
This study evaluated the effect of counterions on the physicochemical properties of prazosin
salts. Salt forms of prazosin, namely, mesylate, besylate, tosylate, camsylate, oxalate, and …

Ditosylate salt of itraconazole and dissolution enhancement using cyclodextrins

N Kumar, Shishu, G Bansal, S Kumar, AK Jana - AAPS PharmSciTech, 2012 - Springer
Salt formation has been a promising approach for improving the solubility of poorly soluble
acidic and basic drugs. The aim of the present study was to prepare the salt form of …

Pharmacokinetic and metabolic studies of Vortioxetine in rats using ultra high performance liquid chromatography with tandem mass spectrometry

S Guan, Y Zou, B Jia, L Wu, Z Yang… - Journal of separation …, 2018 - Wiley Online Library
Vortioxetine is a multimodal antidepressant that has been recently utilized globally.
Vortioxetine hemi‐hydrochloride is a novel salt that was previously reported in our research …