Hyperpolarized isotope-labeled agents have significantly advanced nuclear magnetic
resonance spectroscopy and imaging (MRS/MRI) of physicochemical activities at molecular …

Nuclear hyperpolarization has emerged as a method to dramatically enhance the sensitivity
of NMR spectroscopy. By application of this powerful tool, small molecules with stable …

Here, we show how signal amplification by reversible exchange hyperpolarization of a
range of 15N-containing synthons can be used to enable studies of their reactivity by 15N …

Hyperpolarization modalities overcome the sensitivity limitations of NMR and unlock new
applications. Signal amplification by reversible exchange (SABRE) is a particularly cheap …

Peptides play essential roles in biological phenomena, and, thus, there is a growing interest
in detecting in vivo dynamics of peptide metabolisms. Dissolution-dynamic nuclear …

Hyperpolarization of 13C-pyruvate via Signal Amplificaton By Reversibble Exchange
(SABRE) is an important recent discovery because of both the relative simplicity of …

Hyperpolarized 13 C tracers offer a radiation-free option for metabolic imaging. Signal
enhancement of an order of several thousand times with the dynamic nuclear polarization …

Deuterated 13C sites in sugars (D‐glucose and 2‐deoxy‐D‐glucose) showed 6.3‐to‐17.5‐
fold higher solid‐state dynamic nuclear polarization (DNP) levels than their respective …

Hyperpolarized 15N sites have been found to be promising for generating long‐lived
hyperpolarized states in solution, and present a promising approach for utilizing dissolution …

Magnetic resonance imaging examinations are frequently carried out using contrast agents
to improve the image quality. Practically all clinically used contrast agents are based on …