Alternative polyadenylation of mRNA precursors
Alternative polyadenylation (APA) is an RNA-processing mechanism that generates distinct
3′ termini on mRNAs and other RNA polymerase II transcripts. It is widespread across all …
3′ termini on mRNAs and other RNA polymerase II transcripts. It is widespread across all …
Alternative cleavage and polyadenylation: extent, regulation and function
The 3′ end of most protein-coding genes and long non-coding RNAs is cleaved and
polyadenylated. Recent discoveries have revealed that a large proportion of these genes …
polyadenylated. Recent discoveries have revealed that a large proportion of these genes …
Alternative mRNA transcription, processing, and translation: insights from RNA sequencing
E de Klerk, P AC't Hoen - Trends in Genetics, 2015 - cell.com
The human transcriptome comprises> 80000 protein-coding transcripts and the estimated
number of proteins synthesized from these transcripts is in the range of 250000 to 1 million …
number of proteins synthesized from these transcripts is in the range of 250000 to 1 million …
Ubiquitously transcribed genes use alternative polyadenylation to achieve tissue-specific expression
More than half of human genes use alternative cleavage and polyadenylation (ApA) to
generate mRNA transcripts that differ in the lengths of their 3′ untranslated regions (UTRs) …
generate mRNA transcripts that differ in the lengths of their 3′ untranslated regions (UTRs) …
Targeting mRNA processing as an anticancer strategy
J Desterro, P Bak-Gordon… - Nature Reviews Drug …, 2020 - nature.com
Discoveries in the past decade have highlighted the potential of mRNA as a therapeutic
target for cancer. Specifically, RNA sequencing revealed that, in addition to gene mutations …
target for cancer. Specifically, RNA sequencing revealed that, in addition to gene mutations …
Analysis of alternative cleavage and polyadenylation by 3′ region extraction and deep sequencing
Alternative cleavage and polyadenylation (APA) generates diverse mRNA isoforms. We
developed 3′ region extraction and deep sequencing (3′ READS) to address mispriming …
developed 3′ region extraction and deep sequencing (3′ READS) to address mispriming …
Global analyses of the effect of different cellular contexts on microRNA targeting
MicroRNA (miRNA) regulation clearly impacts animal development, but the extent to which
development—with its resulting diversity of cellular contexts—impacts miRNA regulation is …
development—with its resulting diversity of cellular contexts—impacts miRNA regulation is …
Alternative cleavage and polyadenylation: the long and short of it
Cleavage and polyadenylation (C/P) of nascent transcripts is essential for maturation of the
3′ ends of most eukaryotic mRNAs. Over the past three decades, biochemical studies have …
3′ ends of most eukaryotic mRNAs. Over the past three decades, biochemical studies have …
Alternative Polyadenylation: a new frontier in post transcriptional regulation
Polyadenylation of pre-messenger RNA (pre-mRNA) specific sites and termination of their
downstream transcriptions are signaled by unique sequence motif structures such as …
downstream transcriptions are signaled by unique sequence motif structures such as …
[HTML][HTML] Cellular stress alters 3′ UTR landscape through alternative polyadenylation and isoform-specific degradation
Most eukaryotic genes express alternative polyadenylation (APA) isoforms with different 3′
UTR lengths, production of which is influenced by cellular conditions. Here, we show that …
UTR lengths, production of which is influenced by cellular conditions. Here, we show that …