[HTML][HTML] Mechanistic concepts of iron-sulfur protein biogenesis in Biology

JJ Braymer, SA Freibert, M Rakwalska-Bange… - Biochimica et Biophysica …, 2021 - Elsevier
Abstract Iron-sulfur (Fe/S) proteins are present in virtually all living organisms and are
involved in numerous cellular processes such as respiration, photosynthesis, metabolic …

Bacterial approaches for assembling iron-sulfur proteins

K Esquilin-Lebron, S Dubrac, F Barras, JM Boyd - Mbio, 2021 - Am Soc Microbiol
Building iron-sulfur (Fe-S) clusters and assembling Fe-S proteins are essential actions for
life on Earth. The three processes that sustain life, photosynthesis, nitrogen fixation, and …

Impaired respiration elicits SrrAB-dependent programmed cell lysis and biofilm formation in Staphylococcus aureus

AA Mashruwala, A Guchte, JM Boyd - Elife, 2017 - elifesciences.org
Biofilms are communities of microorganisms attached to a surface or each other. Biofilm-
associated cells are the etiologic agents of recurrent Staphylococcus aureus infections …

Destruction and reformation of an iron-sulfur cluster during catalysis by lipoyl synthase

EL McCarthy, SJ Booker - Science, 2017 - science.org
Lipoyl synthase (LipA) catalyzes the last step in the biosynthesis of the lipoyl cofactor, which
is the attachment of two sulfhydryl groups to C6 and C8 of a pendant octanoyl chain. The …

[HTML][HTML] Fe-S cluster biogenesis by the bacterial Suf pathway

M Blahut, E Sanchez, CE Fisher, FW Outten - Biochimica et Biophysica Acta …, 2020 - Elsevier
Biogenesis of iron-sulfur (Fesingle bondS) clusters in an essential process in living
organisms due to the critical role of Fesingle bondS cluster proteins in myriad cell functions …

Virulence and metabolism

AR Richardson - Microbiology spectrum, 2019 - Am Soc Microbiol
Staphylococcus aureus is clearly the most pathogenic member of the Staphylococcaceae.
This is in large part due to the acquisition of an impressive arsenal of virulence factors that …

The Suf iron-sulfur cluster biosynthetic system is essential in Staphylococcus aureus, and decreased Suf function results in global metabolic defects and reduced …

CA Roberts, HM Al-Tameemi… - Infection and …, 2017 - Am Soc Microbiol
Staphylococcus aureus remains a causative agent for morbidity and mortality worldwide.
This is in part a result of antimicrobial resistance, highlighting the need to uncover novel …

Staphylococcus aureus lacking a functional MntABC manganese import system has increased resistance to copper

H Al‐Tameemi, WN Beavers… - Molecular …, 2021 - Wiley Online Library
S. aureus USA300 isolates utilize the copBL and copAZ gene products to prevent Cu
intoxication. We created and examined a ΔcopAZ ΔcopBL mutant strain (cop‐). The cop …

The copBL operon protects Staphylococcus aureus from copper toxicity: CopL is an extracellular membrane–associated copper-binding protein

Z Rosario-Cruz, A Eletsky, NS Daigham… - Journal of Biological …, 2019 - ASBMB
As complications associated with antibiotic resistance have intensified, copper (Cu) is
attracting attention as an antimicrobial agent. Recent studies have shown that copper …

The Staphylococcus aureus SrrAB Regulatory System Modulates Hydrogen Peroxide Resistance Factors, Which Imparts Protection to Aconitase during Aerobic …

AA Mashruwala, JM Boyd - PLoS One, 2017 - journals.plos.org
The SrrAB two-component regulatory system (TCRS) positively influences the transcription
of genes involved in aerobic respiration in response to changes in respiratory flux. Hydrogen …