Metabolomic epidemiology is the high-throughput study of the relationship between
metabolites and health-related traits. This emerging and rapidly growing field has improved …

Calorie restriction (CR) and fasting are common approaches to weight reduction, but the
maintenance is difficult after resuming food consumption. Meanwhile, the gut microbiome …

Alterations in metabolic pathways are a hallmark of cancer. A deeper understanding of the
contribution of different metabolites to carcinogenesis is thus vitally important to elucidate …

Background & Aims The liver is a metabolically active organ and is also 'tolerogenic',
exhibiting sophisticated mechanisms of immune regulation that prevent pathogen attacks …

The gut microbiome can play a crucial role in hepatocellular carcinoma (HCC) progression
through the enterohepatic circulation, primarily acting via metabolic reprogramming and …

Abstract Context Bile acids (BAs) are pivotal signaling molecules that regulate energy
metabolism and inflammation. Recent epidemiological studies have reported specific …

Bile is a unique body fluid synthesized in our liver. Enterohepatic circulation preserves bile
in our body through its efficient synthesis, transport, absorption, and reuptake. Bile is the …

Hepatobiliary cancers, including hepatocellular carcinoma and cancers of the biliary tract,
share high mortality and rising incidence rates. They may also share several risk factors …

Colon cancer incidence is associated with a high-fat diet. Such a diet is linked to elevated
levels of bile acids in the gastrointestinal system and the circulation. Secondary bile acids …

Background & Aims Hepatocellular carcinoma (HCC) is a male-dominant disease, but
targeted sex hormone therapies have not been successful. Bile acids are a potential liver …