[HTML][HTML] Nutrition, longevity and disease: From molecular mechanisms to interventions

VD Longo, RM Anderson - Cell, 2022 - cell.com
Diet as a whole, encompassing food composition, calorie intake, and the length and
frequency of fasting periods, affects the time span in which health and functional capacity …

Clinical application of intermittent fasting for weight loss: progress and future directions

KA Varady, S Cienfuegos, M Ezpeleta… - Nature Reviews …, 2022 - nature.com
Intermittent fasting diets have become very popular in the past few years, as they can
produce clinically significant weight loss. These diets can be defined, in the simplest of …

Brain energy rescue: an emerging therapeutic concept for neurodegenerative disorders of ageing

SC Cunnane, E Trushina, C Morland… - Nature reviews Drug …, 2020 - nature.com
The brain requires a continuous supply of energy in the form of ATP, most of which is
produced from glucose by oxidative phosphorylation in mitochondria, complemented by …

Hallmarks of cardiovascular ageing

M Abdellatif, PP Rainer, S Sedej… - Nature Reviews …, 2023 - nature.com
Normal circulatory function is a key determinant of disease-free life expectancy (healthspan).
Indeed, pathologies affecting the cardiovascular system, which are growing in prevalence …

Intermittent fasting in the prevention and treatment of cancer

KK Clifton, CX Ma, L Fontana… - CA: a cancer journal for …, 2021 - Wiley Online Library
Chronic caloric restriction (CR) has powerful anticarcinogenic actions in both preclinical and
clinical studies but may be difficult to sustain. As an alternative to CR, there has been …

Cardiometabolic benefits of intermittent fasting

KA Varady, S Cienfuegos, M Ezpeleta… - Annual review of …, 2021 - annualreviews.org
This review aims to summarize the effects of intermittent fasting on markers of
cardiometabolic health in humans. All forms of fasting reviewed here—alternate-day fasting …

A randomized controlled trial to isolate the effects of fasting and energy restriction on weight loss and metabolic health in lean adults

I Templeman, HA Smith, E Chowdhury… - Science translational …, 2021 - science.org
Intermittent fasting may impart metabolic benefits independent of energy balance by
initiating fasting-mediated mechanisms. This randomized controlled trial examined 24-hour …

Thyroid hormones in diabetes, cancer, and aging

BR Gauthier, A Sola‐García, MÁ Cáliz‐Molina… - Aging cell, 2020 - Wiley Online Library
Thyroid function is central in the control of physiological and pathophysiological processes.
Studies in animal models and human research have determined that thyroid hormones …

Intermittent fasting: from calories to time restriction

E Duregon, LCDD Pomatto-Watson, M Bernier… - Geroscience, 2021 - Springer
The global human population has recently experienced an increase in life expectancy with a
mounting concern about the steady rise in the incidence of age-associated chronic diseases …

Effect of epidemic intermittent fasting on cardiometabolic risk factors: a systematic review and meta-analysis of randomized controlled trials

F Yang, C Liu, X Liu, X Pan, X Li, L Tian, J Sun… - Frontiers in …, 2021 - frontiersin.org
Intermittent fasting (IF) has gained attention as a promising diet for weight loss and
dysmetabolic diseases management. This systematic review aimed to investigate the effects …