T cell subsets and their signature cytokines in autoimmune and inflammatory diseases
Abstract CD4+ T helper (Th) cells are critical for proper immune cell homeostasis and host
defense, but are also major contributors to pathology of autoimmune and inflammatory …
defense, but are also major contributors to pathology of autoimmune and inflammatory …
Targeting interferon-γ in hyperinflammation: opportunities and challenges
F De Benedetti, G Prencipe, C Bracaglia… - Nature Reviews …, 2021 - nature.com
Interferon-γ (IFNγ) is a pleiotropic cytokine with multiple effects on the inflammatory
response and on innate and adaptive immunity. Overproduction of IFNγ underlies several …
response and on innate and adaptive immunity. Overproduction of IFNγ underlies several …
Modular transcriptional repertoire analyses of adults with systemic lupus erythematosus reveal distinct type I and type II interferon signatures
L Chiche, N Jourde‐Chiche, E Whalen… - Arthritis & …, 2014 - Wiley Online Library
Objective The role of interferon‐α (IFNα) in the pathogenesis of systemic lupus
erythematosus (SLE) is strongly supported by gene expression studies. The aim of this study …
erythematosus (SLE) is strongly supported by gene expression studies. The aim of this study …
Molecular mechanisms regulating Th1 immune responses
SJ Szabo, BM Sullivan, SL Peng… - Annual review of …, 2003 - annualreviews.org
The T helper lymphocyte is responsible for orchestrating the appropriate immune response
to a wide variety of pathogens. The recognition of the polarized T helper cell subsets Th1 …
to a wide variety of pathogens. The recognition of the polarized T helper cell subsets Th1 …
Understanding the IL-23–IL-17 immune pathway
BS McKenzie, RA Kastelein, DJ Cua - Trends in immunology, 2006 - cell.com
Interleukin (IL)-23 is a heterodimeric cytokine closely related to IL-12. Yet, despite a strong
structural relationship that includes a shared p40 subunit, this does not translate into …
structural relationship that includes a shared p40 subunit, this does not translate into …
The role of flavonoids in autoimmune diseases: Therapeutic updates
Flavonoids are natural polyphenolic compounds which are included in a panoply of drugs
and used to treat and/or manage human ailments such as metabolic, cardiovascular …
and used to treat and/or manage human ailments such as metabolic, cardiovascular …
[HTML][HTML] Interferon-γ and systemic autoimmunity
KM Pollard, DM Cauvi, CB Toomey, KV Morris… - Discovery …, 2013 - ncbi.nlm.nih.gov
The term interferon describes a family of proteins consisting of three major types (I, II, III)
which differ in their primary protein sequences, cognate receptors, genetic loci, and cell …
which differ in their primary protein sequences, cognate receptors, genetic loci, and cell …
T-box transcription factor T-bet, a key player in a unique type of B-cell activation essential for effective viral clearance
K Rubtsova, AV Rubtsov, LF van Dyk… - Proceedings of the …, 2013 - National Acad Sciences
IgG2a is known to be the most efficient antibody isotype for viral clearance. Here, we
demonstrate a unique pathway of B-cell activation, leading to IgG2a production, and …
demonstrate a unique pathway of B-cell activation, leading to IgG2a production, and …
Biologic functions of the IFN‐γ receptors
G Tau, P Rothman - Allergy, 2001 - pmc.ncbi.nlm.nih.gov
Interferon-gamma (IFN-c) is a cytokine that plays an important role in inducing and
modulating an array of immune responses. Cellular responses to IFN-c are mediated by its …
modulating an array of immune responses. Cellular responses to IFN-c are mediated by its …
IFN-γ, should not be ignored in SLE
W Liu, S Zhang, J Wang - Frontiers in Immunology, 2022 - frontiersin.org
Systemic lupus erythematosus (SLE) is a typical autoimmune disease with a complex
pathogenesis and genetic predisposition. With continued understanding of this disease, it …
pathogenesis and genetic predisposition. With continued understanding of this disease, it …