Numerous drug treatments that have recently entered the clinic or clinical trials have their
genesis in zebrafish. Zebrafish are well established for their contribution to developmental …

The RASopathies are a group of disorders caused by a germline mutation in one of the
genes encoding a component of the RAS/MAPK pathway. These disorders, including …

Congenital heart disease (CHD) is one of the most common birth defects. Studies in animal
models and humans have indicated a genetic etiology for CHD. About 400 genes have been …

Abstract Noonan syndrome [NS; Mendelian Inheritance in Men (MIM)# 163950] and related
syndromes [Noonan syndrome with multiple lentigines (formerly called LEOPARD …

Animal development is characterized by signaling events that occur at precise locations and
times within the embryo, but determining when and where such precision is needed for …

Living systems exhibit remarkable abilities to self-assemble, regenerate, and remodel
complex shapes. How cellular networks construct and repair specific anatomical outcomes …

Transcriptional enhancers direct precise gene expression patterns during development and
harbor the majority of variants associated with phenotypic diversity, evolutionary …

Histiocytic sarcoma is a rare malignant neoplasm that may occur de novo or in the context of
a previous hematologic malignancy or mediastinal germ cell tumor. Here, we performed …

Highlights•Distinct cell fates result from different spatiotemporal MAPK dynamics.•Versatile
MAPK dynamics include adaptive/sustained activity, switches and oscillations.•MAPK …

Gap junctions (GJs) are aqueous channels that allow cells to communicate via physiological
signals directly. The role of gap junctional connectivity in determining single‐cell functions …