Simple Summary MMP9, due to its proteolytic activity, plays a key role in tumorigenesis by
regulating migration, epithelial-to-mesenchymal transition and survival of cancer cells …

Functions of individual matrix metalloproteinases (MMPs) differentially expressed by tumor
cells and stromal cells, are finely regulated by their spatial as well as temporal interactions …

Matrix metalloproteinases (MMPs) are the major protease family responsible for the
cleavage of the matrisome (global composition of the extracellular matrix (ECM) proteome) …

Gelatin zymography is a simple yet powerful method to detect proteolytic enzymes capable
of degrading gelatin from various biological sources. It is particularly useful for the …

Matrix metalloproteinases (MMPs) are zinc-dependent proteolytic enzymes that degrade
various proteins in the extracellular matrix (ECM). MMPs may also regulate the activity of …

Cancer is the final result of uninhibited cell growth that involves an enormous group of
associated diseases. One major aspect of cancer is when cells attack adjacent components …

Proteases are crucial for development, tissue remodeling, and tumorigenesis. Matrix
metalloproteinases (MMPs) family, in particular, consists of more than 20 members with …

This short review highlights some recent advances in matrix metalloproteinase inhibitor
(MMPi) design and development. Three distinct approaches to improved MMP inhibition are …

Systemic inflammatory events, such as infection, increase the risk of stroke and are
associated with worse outcome, but the mediators of this clinically important effect are …

Simple Summary Proteolytic enzymes, such as matrix metalloproteinases, plasminogen
activators and cathepsins, as well as non-proteolytic enzymatic partners, such as …