Virologs, viral mimicry, and virocell metabolism: the expanding scale of cellular functions encoded in the complex genomes of giant viruses

M Moniruzzaman, MP Erazo Garcia… - FEMS microbiology …, 2023 - academic.oup.com
The phylum Nucleocytoviricota includes the largest and most complex viruses known. These
“giant viruses” have a long evolutionary history that dates back to the early diversification of …

More than 18,000 effectors in the Legionella genus genome provide multiple, independent combinations for replication in human cells

L Gomez-Valero, C Rusniok… - Proceedings of the …, 2019 - National Acad Sciences
The genus Legionella comprises 65 species, among which Legionella pneumophila is a
human pathogen causing severe pneumonia. To understand the evolution of an …

Megaviruses contain various genes encoding for eukaryotic vesicle trafficking factors

D Khalifeh, E Neveu, D Fasshauer - Traffic, 2022 - Wiley Online Library
Many intracellular pathogens, such as bacteria and large viruses, enter eukaryotic cells via
phagocytosis, then replicate and proliferate inside the host. To avoid degradation in the …

Resolving ancient gene transfers clarifies the early co-evolution of eukaryotes and giant viruses

S Karki, FO Aylward - bioRxiv, 2023 - biorxiv.org
Members of the phylum Nucleocytoviricota, also called “giant viruses” due to their large
physical dimensions and genome lengths, are a diverse group of dsDNA viruses that infect a …

Role of an FNIP repeat domain-containing protein encoded by Megavirus baoshan during viral infection

Y Xia, H Cheng, W Bian, W Wang, M Zhu… - Journal of …, 2022 - Am Soc Microbiol
ABSTRACT FNIP repeat domain-containing protein (FNIP protein) is a little-studied atypical
leucine-rich repeat domain-containing protein found in social amoebae and mimiviruses …

The number of genes encoding repeat domain-containing proteins positively correlates with genome size in amoebal giant viruses

A Shukla, A Chatterjee, K Kondabagil - Virus evolution, 2018 - academic.oup.com
Curiously, in viruses, the virion volume appears to be predominantly driven by genome
length rather than the number of proteins it encodes or geometric constraints. With their …

Rab5 enhances classical swine fever virus proliferation and interacts with viral NS4B protein to facilitate formation of NS4B related complex

J Lin, C Wang, L Zhang, T Wang, J Zhang… - Frontiers in …, 2017 - frontiersin.org
Classical swine fever virus (CSFV) is a fatal pig pestivirus and causes serious financial
losses to the pig industry. CSFV NS4B protein is one of the most important viral replicase …

Crystal structures of two forms of the Acanthamoeba polyphaga mimivirus Rab GTPase

B Ku, JA You, KJ Oh, HY Yun, HS Lee, HC Shin… - Archives of …, 2017 - Springer
Acanthamoeba polyphaga mimivirus (APMV) is a member of the family of giant viruses,
harboring a 1,200 kbp genome within its 700 nm-diameter viral particle. The R214 gene of …

Evolution de la virulence et du spectre d'hôtes chez la bactérie pathogène émergente Legionella pneumophila

G Carrillo - 2023 - theses.hal.science
Les bactéries du genre Legionella sont responsables chez l'homme d'une maladie appelée
légionellose. Cette forme aiguë de pneumonie peut être mortelle dans 7 à 30% des cas …

[PDF][PDF] Detection of heat shock protein (DnaK, DnaJ and GrpE) horizontal gene transfers among Acanthamoeba polyphaga, Acanthamoeba polyphaga mimivirus …

M Haghi, AE Koseoglu, I Karaboz, C Un - Int J Adv Biotechnol Res, 2016 - researchgate.net
Acanthamoeba polyphaga mimivirus (APMV) was isolated in 1992.. It's large size, gram
positivity and unique genome features attracted many scientists attention in evolutinary and …