Perineural invasion (PNI) is the process of neoplastic invasion of peripheral nerves and is
considered to be the fifth mode of cancer metastasis. PNI has been detected in head and …

Gastrointestinal (GI) cancer is a formidable malignancy with significant morbidity and
mortality rates. Recent studies have shed light on the complex interplay between the …

Long noncoding RNAs, a newly identified class of noncoding RNAs, are important
regulators of gene expression in innate immunity. We report in this study that the …

Background The perineural invasion (PNI)-mediated inflammation of the tumor
microenvironment (TME) varies among gastric cancer (GC) patients and exhibits a close …

Understanding the molecular mechanisms regulating tumor dissemination and therapeutic
resistance is of central importance for effective cancer therapies. Here, we report that nerve …

Background The aim of the present study was to evaluate the prognostic significance of
perineural invasion (PNI) in locally advanced gastric cancer patients who underwent D2 …

The nervous system has been recently shown to exert impact on gastric cancer directly and
indirectly. Gastric cancer cells invade nerve fibers to induce outgrowth and branching of …

Aims The prognostic significance of perineural invasion (PNI) for gastric cancer (GC)
patients was under debate. This study aimed to review relevant studies and evaluate the …

Background Perineural invasion (PNI) is regarded as a prognostic factor for patients with
GC. However, the significance of PNI in patients with stage II GC remains unclear. This study …

The vagus nerve (VN) is the main parasympathetic nerve of the autonomic nervous system.
It is widely distributed in the gastrointestinal tract and maintains gastrointestinal homeostasis …