Innate immune dysfunction and neuroinflammation in autism spectrum disorder (ASD)

HK Hughes, RJ Moreno, P Ashwood - Brain, behavior, and immunity, 2023 - Elsevier
Autism spectrum disorder (ASD) is a highly heterogeneous neurodevelopmental disorder
characterized by communication and social behavior deficits. The presence of restricted and …

Autoimmunity and organ damage in systemic lupus erythematosus

GC Tsokos - Nature immunology, 2020 - nature.com
Impressive progress has been made over the last several years toward understanding how
almost every aspect of the immune system contributes to the expression of systemic …

The neuropathology of autism: A systematic review of post-mortem studies of autism and related disorders

R Fetit, RF Hillary, DJ Price, SM Lawrie - Neuroscience & Biobehavioral …, 2021 - Elsevier
Post-mortem studies allow for the direct investigation of brain tissue in those with autism and
related disorders. Several review articles have focused on aspects of post-mortem …

Astrocytes derived from ASD individuals alter behavior and destabilize neuronal activity through aberrant Ca2+ signaling

M Allen, BS Huang, MJ Notaras, A Lodhi… - Molecular …, 2022 - nature.com
The cellular mechanisms of autism spectrum disorder (ASD) are poorly understood.
Cumulative evidence suggests that abnormal synapse function underlies many features of …

Association of peripheral blood levels of cytokines with autism spectrum disorder: A meta-analysis

H Zhao, H Zhang, S Liu, W Luo, Y Jiang… - Frontiers in psychiatry, 2021 - frontiersin.org
Background: Although increasing evidence suggests an association between alterations in
peripheral cytokines and autism spectrum disorder (ASD), a consensus is lacking. To …

Pathology and astrocytes in autism

G Vakilzadeh, V Martinez-Cerdeño - Neuropsychiatric Disease and …, 2023 - Taylor & Francis
A distinct pathology for autism spectrum disorder (ASD) remains elusive. Human and animal
studies have focused on investigating the role of neurons in ASD. However, recent studies …

Immunoregulatory and/or anti-inflammatory agents for the management of core and associated symptoms in individuals with autism spectrum disorder: A narrative …

G Arteaga-Henriquez, L Gisbert, JA Ramos-Quiroga - CNS drugs, 2023 - Springer
Autism spectrum disorder (ASD) is a heterogeneous neurodevelopmental condition with a
so far poorly understood underlying pathogenesis, and few effective therapies for core …

Guggulsterone mediated JAK/STAT and PPAR-gamma modulation prevents neurobehavioral and neurochemical abnormalities in propionic acid-induced …

R Khera, S Mehan, S Bhalla, S Kumar, A Alshammari… - Molecules, 2022 - mdpi.com
Autism spectrum disorder is a neurodevelopmental disorder marked by repetitive behaviour,
challenges in verbal and non-verbal communication, poor socio-emotional health, and …

Re-emerging concepts of immune dysregulation in autism spectrum disorders

A Erbescu, SM Papuc, M Budisteanu, A Arghir… - Frontiers in …, 2022 - frontiersin.org
Autism spectrum disorder (ASD) is a neurodevelopmental condition characterized by
communication and social interaction deficits, and by restricted interests and stereotyped …

Prenatal and postnatal neuroimmune interactions in neurodevelopmental disorders

E Kim, JR Huh, GB Choi - Nature Immunology, 2024 - nature.com
The intricate relationship between immune dysregulation and neurodevelopmental
disorders (NDDs) has been observed across the stages of both prenatal and postnatal …