Interferon-γ: teammate or opponent in the tumour microenvironment?

AM Gocher, CJ Workman, DAA Vignali - Nature Reviews Immunology, 2022 - nature.com
Cancer immunotherapy offers substantive benefit to patients with various tumour types, in
some cases leading to complete tumour clearance. However, many patients do not respond …

Overview of the IL‐1 family in innate inflammation and acquired immunity

CA Dinarello - Immunological reviews, 2018 - Wiley Online Library
Summary The interleukin‐1 (IL‐1) family of cytokines and receptors is unique in immunology
because the IL‐1 family and Toll‐like receptor (TLR) families share similar functions. More …

Interleukin 33 is a guardian of barriers and a local alarmin

NT Martin, MU Martin - Nature immunology, 2016 - nature.com
Abstract Interleukin 33 (IL-33) is a member of the IL-1 family of cytokines with a growing
number of target cells and a plethora of biological functions. Although it has commonalities …

[HTML][HTML] Liver-resident NK cells control antiviral activity of hepatic T cells via the PD-1-PD-L1 axis

J Zhou, H Peng, K Li, K Qu, B Wang, Y Wu, L Ye… - Immunity, 2019 - cell.com
The tolerogenic microenvironment of the liver is associated with impaired hepatic T cell
function. Here, we examined the contribution of liver-resident natural killer (LrNK) cells, a …

Dual immune regulatory roles of interleukin-33 in pathological conditions

H Guo, EA Bossila, X Ma, C Zhao, Y Zhao - Cells, 2022 - mdpi.com
Interleukin-33 (IL-33), a member of the IL-1 cytokine family and a multifunctional cytokine,
plays critical roles in maintaining host homeostasis and in pathological conditions, such as …

The pleiotropic immunomodulatory functions of IL-33 and its implications in tumor immunity

C Afferni, C Buccione, S Andreone… - Frontiers in …, 2018 - frontiersin.org
Interleukin-33 (IL-33) is a IL-1 family member of cytokines exerting pleiotropic activities. In
the steady-state, IL-33 is expressed in the nucleus of epithelial, endothelial, and fibroblast …

Cytokines and their role as immunotherapeutics and vaccine Adjuvants: The emerging concepts

T Rahman, A Das, MH Abir, IH Nafiz, AR Mahmud… - Cytokine, 2023 - Elsevier
Cytokines are a protein family comprising interleukins, lymphokines, chemokines,
monokines and interferons. They are significant constituents of the immune system, and they …

Engineering γδ T cells: recognizing and activating on their own way

R Dong, Y Zhang, H Xiao, X Zeng - Frontiers in immunology, 2022 - frontiersin.org
Adoptive cell therapy (ACT) with engineered T cells has emerged as a promising strategy for
the treatment of malignant tumors. Among them, there is great interest in engineered γδ T …

WFDC2 promotes spasmolytic polypeptide-expressing metaplasia through the up-regulation of IL33 in response to injury

H Jeong, B Lee, KH Kim, SY Cho, Y Cho, J Park, Y Lee… - Gastroenterology, 2021 - Elsevier
Background & Aims WAP 4-disulfide core domain protein 2 (WFDC2), also known as human
epididymis protein 4, is a small secretory protein that is highly expressed in fibrosis and …

The janus face of IL-33 signaling in tumor development and immune escape

MR Choi, JA Sosman, B Zhang - Cancers, 2021 - mdpi.com
Simple Summary Interleukin-33 (IL-33) is often released from damaged cells, acting as a
danger signal. IL-33 exerts its function by interacting with its receptor suppression of …