Extracellular biophysical properties have particular implications for a wide spectrum of
cellular behaviors and functions, including growth, motility, differentiation, apoptosis, gene …

Epigenetic mechanisms, including DNA methylation, histone modifications, and non-coding
RNA, play a crucial role in the regulation of gene expression and are pivotal in biological …

Salt-inducible kinases (SIKs) are serine/threonine kinases belonging to the AMP-activated
protein kinase (AMPK) family. Accumulating evidence indicates that SIKs phosphorylate …

Background: Similarities in the biology of pulmonary hypertension and cancer suggest that
anticancer therapies, such as sanguinarine, may also be effective in treating pulmonary …

Inflammation can positively and negatively affect tumorigenesis based on the duration,
scope, and sequence of related events through the regulation of signaling pathways. A …

Pulmonary hypertension (PH) is a general term used to describe high blood pressure in the
lungs from any cause. Pulmonary arterial hypertension (PAH) is a progressive, and fatal …

Pulmonary hypertension (PH) is a progressive, severe and to date not curable disease of the
pulmonary vasculature. Alterations of the insulin-like growth factor 1 (IGF-1) system are …

Abstract Treatment modalities for pulmonary arterial hypertension (PAH) improve quality of
life and walk distance. However, none of these therapies alter the structural/functional …

In the land of Ancient Egypt, where the Pharaonic civilization flourished, one can encounter
sophisticated methods of treating human illnesses. The Ancient Egyptians considered a …

This study test was designed to investigate the possible modulatory effect of rapamycin
combined with HO-3867 in monocrotaline (MCT)-induced pulmonary arterial hypertension in …