Targeting metabolic dysregulation for fibrosis therapy

X Zhao, JYY Kwan, K Yip, PP Liu, FF Liu - Nature reviews Drug …, 2020 - nature.com
Fibrosis is the abnormal deposition of extracellular matrix, which can lead to organ
dysfunction, morbidity, and death. The disease burden caused by fibrosis is substantial, and …

Metabolomics in diabetes and diabetic complications: insights from epidemiological studies

Q Jin, RCW Ma - Cells, 2021 - mdpi.com
The increasing prevalence of diabetes and its complications, such as cardiovascular and
kidney disease, remains a huge burden globally. Identification of biomarkers for the …

Lipidomic approaches to dissect dysregulated lipid metabolism in kidney disease

J Baek, C He, F Afshinnia, G Michailidis… - Nature Reviews …, 2022 - nature.com
Dyslipidaemia is a hallmark of chronic kidney disease (CKD). The severity of dyslipidaemia
not only correlates with CKD stage but is also associated with CKD-associated …

[HTML][HTML] Diagnosis of diabetic kidney disease: state of the art and future perspective

F Persson, P Rossing - Kidney international supplements, 2018 - Elsevier
Approximately 20% to 40% of patients with type 1 or type 2 diabetes mellitus develop
diabetic kidney disease. This is a clinical syndrome characterized by persistent albuminuria …

[HTML][HTML] Gut microbiota and diabetes: From correlation to causality and mechanism

WZ Li, K Stirling, JJ Yang, L Zhang - World journal of diabetes, 2020 - ncbi.nlm.nih.gov
In this review, we summarize the recent microbiome studies related to diabetes disease and
discuss the key findings that show the early emerging potential causal roles for diabetes. On …

Biomarkers of diabetic kidney disease

HM Colhoun, ML Marcovecchio - Diabetologia, 2018 - Springer
Diabetic kidney disease (DKD) remains one of the leading causes of reduced lifespan in
diabetes. The quest for both prognostic and surrogate endpoint biomarkers for advanced …

Metabolomics as a tool for the early diagnosis and prognosis of diabetic kidney disease

PR Pereira, DF Carrageta, PF Oliveira… - Medicinal Research …, 2022 - Wiley Online Library
Diabetic kidney disease (DKD) is one of the most prevalent comorbidities of diabetes
mellitus and the leading cause of the end‐stage renal disease (ESRD). DKD results from …

The gut–kidney axis

P Evenepoel, R Poesen, B Meijers - Pediatric Nephrology, 2017 - Springer
The host–gut microbiota interaction has been the focus of increasing interest in recent years.
It has been determined that this complex interaction is not only essential to many aspects of …

The roles of gut microbiota and its metabolites in diabetic nephropathy

H Zhao, CE Yang, T Liu, MX Zhang, Y Niu… - Frontiers in …, 2023 - frontiersin.org
Diabetic nephropathy (DN) is a severe microvascular complication of diabetes, which
increases the risk of renal failure and causes a high global disease burden. Due to the lack …

Inhibiting aerobic glycolysis suppresses renal interstitial fibroblast activation and renal fibrosis

H Ding, L Jiang, J Xu, F Bai, Y Zhou… - American Journal …, 2017 - journals.physiology.org
Chronic kidney diseases generally lead to renal fibrosis. Despite great progress having
been made in identifying molecular mediators of fibrosis, the mechanism that governs renal …