The direct functionalization of C (sp3)–H bonds represents one of the most investigated
approaches to develop new synthetic methodology. Among the available strategies for …

Synthetic chemistry plays an indispensable role in drug discovery, contributing to hit
compounds identification, lead compounds optimization, candidate drugs preparation, and …

Recognizing Nature's unique ability to perform challenging oxygenation reactions with
exquisite selectivity parameters at iron-dependent oxygenases, chemists have long sought …

The development of catalytic systems capable of oxygenating unactivated C–H bonds with
excellent site-selectivity and functional group tolerance under mild conditions remains a …

An emerging trend in small-molecule pharmaceuticals, generally composed of nitrogen
heterocycles (N-heterocycles), is the incorporation of aliphatic fragments. Derivatization of …

Detailed herein are our synthesis studies of longiborneol and related natural products. Our
overarching goals of utilizing a “camphor first” strategy enabled by skeletal remodeling of …

Direct hydroxylation via the functionalization of tertiary benzylic C (sp3)–H bonds is of great
significance for obtaining tertiary alcohols, which find wide applications in pharmaceuticals …

Biomimetic iron and manganese complexes have emerged as important catalysts in chemo-,
regio-, and stereoselective oxidation reactions. In this study, we describe a remote …

In recent years, metalloenzymes‐mediated highly selective oxidations of organic substrates
under mild conditions have been inspiration for developing synthetic bioinspired catalyst …

Enones are privileged structural motifs in bioactive natural products and pharmaceuticals,
but the γ-hydroxylation of enones is challenging. Here we show a mild and efficient method …