The clinical symptoms of Parkinson's disease

S Sveinbjornsdottir - Journal of neurochemistry, 2016 - Wiley Online Library
In this review, the clinical features of Parkinson's disease, both motor and non‐motor, are
described in the context of the progression of the disease. Also briefly discussed are the …

Parkinson's disease

A Samii, JG Nutt, BR Ransom - The Lancet, 2004 - thelancet.com
Parkinson's disease is the most common serious movement disorder in the world, affecting
about 1% of adults older than 60 years. The disease is attributed to selective loss of neurons …

The scientific and clinical basis for the treatment of Parkinson disease (2009)

CW Olanow, MB Stern, K Sethi - Neurology, 2009 - AAN Enterprises
Parkinson disease (PD) is an age-related neurodegenerative disorder that affects as many
as 1–2% of persons aged 60 years and older. With the aging of the population, the …

Parkinson's disease: a dual‐hit hypothesis

CH Hawkes, K Del Tredici… - … and applied neurobiology, 2007 - Wiley Online Library
Accumulating evidence suggests that sporadic Parkinson's disease has a long prodromal
period during which several non‐motor features develop, in particular, impairment of …

Parkinson's disease: the dual hit theory revisited

CH Hawkes, K Del Tredici… - Annals of the New York …, 2009 - Wiley Online Library
Accumulating evidence suggests that sporadic Parkinson's disease (sPD) has a long
prodromal period during which several nonmotor features develop; in particular, impairment …

Pains in Parkinson disease—many syndromes under one umbrella

G Wasner, G Deuschl - Nature Reviews Neurology, 2012 - nature.com
Pain is a nonmotor symptom that substantially affects the quality of life of at least one-third of
patients with Parkinson disease (PD). Interestingly, patients with PD frequently report …

The hidden sister of motor fluctuations in Parkinson's disease: A review on nonmotor fluctuations

R Martínez‐Fernández, E Schmitt… - Movement …, 2016 - Wiley Online Library
Only a few years after the introduction of levodopa, the first descriptions of motor fluctuations
and dyskinesia related to dopaminergic therapy appeared. In PD, attention turned to their …

Patient-reported autonomic symptoms in Parkinson disease

D Verbaan, J Marinus, M Visser, SM van Rooden… - Neurology, 2007 - AAN Enterprises
Objective: There is a wide range of autonomic symptoms (AS) in Parkinson disease (PD),
but the full spectrum has never been evaluated with a validated instrument and in …

Parkinson's disease: lesions in dorsal horn layer I, involvement of parasympathetic and sympathetic pre-and postganglionic neurons

H Braak, M Sastre, JRE Bohl, RAI de Vos… - Acta …, 2007 - Springer
Clinical signs frequently recognized in early phases of sporadic Parkinson's disease (PD)
may include autonomic dysfunctions and the experience of pain. Early disease-related …

Nonmotor manifestations of Parkinson's disease

T Simuni, K Sethi - Annals of Neurology: Official Journal of the …, 2008 - Wiley Online Library
Parkinson's disease (PD) is the second most common neurodegenerative disease after
Alzheimer's disease. Traditionally, attention has focused on the motor symptomatology of …