X Li, W Li, M Wang, Z Liao - Journal of Controlled Release, 2021 - Elsevier
Cancer is one of the leading causes of mortality worldwide. Nanoparticles have been broadly studied and emerged as a novel approach in diagnosis and treatment of tumors …
With the recent FDA approval of the first siRNA‐derived therapeutic, RNA interference (RNAi)‐mediated gene therapy is undergoing a transition from research to the clinical …
Z Liu, Q Sun, X Wang - Translational oncology, 2017 - Elsevier
Abstract Polo-like kinase 1 (PLK1) plays an important role in the initiation, maintenance, and completion of mitosis. Dysfunction of PLK1 may promote cancerous transformation and drive …
Superparamagnetic iron oxide nanoparticles (SPIONs) are considered as chemically inert materials and, therefore, being extensively applied in the areas of imaging, targeting, drug …
L Zhu, Z Zhou, H Mao, L Yang - Nanomedicine, 2017 - Taylor & Francis
Recent advances in the development of magnetic nanoparticles (MNPs) have shown promise in the development of new personalized therapeutic approaches for clinical …
T Anani, S Rahmati, N Sultana, AE David - Theranostics, 2021 - ncbi.nlm.nih.gov
Current cancer therapies, including chemotherapy and radiotherapy, are imprecise, non- specific, and are often administered at high dosages-resulting in side effects that severely …
UM Mahajan, E Langhoff, E Goni, E Costello… - Gastroenterology, 2018 - Elsevier
Background & Aims Changes to the microenvironment of pancreatic ductal adenocarcinomas (PDACs) have been associated with poor outcomes of patients. We …
Pancreatic cancer is one of the harshest and most challenging cancers to treat, often labeled as incurable. Chemotherapy continues to be the most popular treatment yet yields a very …
E Alphandéry - Drug discovery today, 2020 - Elsevier
Highlights•IONP therapeutic activity activated by local heat, ROS, drug release.•IONP activation controllable by the application of an external source of energy.•IONP can be …