Cancer cells adapt to increasing energy and biosynthetic demands by reprogramming their
metabolic pathways. Mitochondria are important organelles for the metabolic …

Introduction Drugs targeting mitochondria are emerging as promising antitumor therapeutics
in preclinical models. However, a few of these drugs have shown clinical toxicity …

Germ cell formation and embryonic development require ATP synthesized by mitochondria.
The dynamic system of the mitochondria, and in particular, the fusion of mitochondria, are …

There is new and increasing evidence from in vitro, in vivo and clinical studies implicating
the pivotal role of iron and associated metabolic pathways in the initiation, progression and …

Granulocytes (neutrophils, eosinophils, and basophils) are the most abundant circulating
cells in the innate immune system. Circulating granulocytes, primarily neutrophils, can cross …

The tumor microenvironment affects the structure and metabolic function of mitochondria in
tumor cells. This process involves changes in metabolic activity, an increase in the amount …

Mitochondrial regulation plays a crucial role in cancer immunity in the tumor
microenvironment (TME). Infiltrating immune cells, including T cells, natural killer (NK) cells …

Glycolytic and mitochondrial oxidative metabolism, which are two major energy sources in
tumors, are potential targets in cancer treatment. Metabolic reprogramming from glycolysis to …

N-acetylcysteine (NAC) has been used as an antioxidant drug in tumor cells and preclinical
mice tumor xenografts, and it improves adaptive immunotherapy in melanoma. NAC is not …

Black and Hispanic cancer patients have a higher incidence of cancer mortality. Many
factors (eg, socioeconomic differences, insufficient access to healthcare) contribute to racial …