Members of the Prdm family are characterized by an N-terminal PR domain that is related to
the SET methyltransferase domain, and multiple zinc fingers that mediate sequence-specific …

The treatment of cancer through the development of new therapies is one of the most
important challenges of our time. The decoding of the human genome has yielded important …

Gene-modified autologous hematopoietic stem cells (HSC) can provide ample clinical
benefits to subjects suffering from X-linked chronic granulomatous disease (X-CGD), a rare …

The messenger RNA (mRNA) from 5 of 69 patients with severe hemophilia A did not support
amplification of complementary DNA containing the first few exons of the factor VIII (F8) gene …

PRDI-BF1, the human ortholog of mouse Blimp-1, is a DNA-binding protein involved in
postinduction repression of interferon-β gene transcription in response to viral infection …

Purpose Acute myeloid leukemia (AML) with inv (3)(q21q26. 2)/t (3; 3)(q21; q26. 2)[inv (3)/t
(3; 3)] is recognized as a distinctive entity in the WHO classification. Risk assignment and …

Evi-1 has been recognized as one of the dominant oncogenes associated with murine and
human myeloid leukemia. Here, we show that hematopoietic stem cells (HSCs) in Evi-1 …

Inappropriate expression of EVI1 (ecotropic virus integration-1), in particular splice form
EVI1-1D, through chromosome 3q26 lesions or other mechanisms has been implicated in …

The PRDM family has recently spawned considerable interest as it has been implicated in
fundamental aspects of cellular differentiation and exhibits expanding ties to human …

Transcription of a gene usually ends at a regulated termination point, preventing the RNA-
polymerase from reading through the next gene. However, sporadic reports suggest that …