How the immune system shapes atherosclerosis: roles of innate and adaptive immunity
Atherosclerosis is the root cause of many cardiovascular diseases. Extensive research in
preclinical models and emerging evidence in humans have established the crucial roles of …
preclinical models and emerging evidence in humans have established the crucial roles of …
How vascular smooth muscle cell phenotype switching contributes to vascular disease
G Cao, X Xuan, J Hu, R Zhang, H Jin… - Cell Communication and …, 2022 - Springer
Vascular smooth muscle cells (VSMCs) are the most abundant cell in vessels. Earlier
experiments have found that VSMCs possess high plasticity. Vascular injury stimulates …
experiments have found that VSMCs possess high plasticity. Vascular injury stimulates …
Single-cell genomics reveals a novel cell state during smooth muscle cell phenotypic switching and potential therapeutic targets for atherosclerosis in mouse and …
Background: Smooth muscle cells (SMCs) play significant roles in atherosclerosis via
phenotypic switching, a pathological process in which SMC dedifferentiation, migration, and …
phenotypic switching, a pathological process in which SMC dedifferentiation, migration, and …
Vascular smooth muscle cells in atherosclerosis: time for a re-assessment
MOJ Grootaert, MR Bennett - Cardiovascular research, 2021 - academic.oup.com
Vascular smooth muscle cells (VSMCs) are key participants in both early and late-stage
atherosclerosis. VSMCs invade the early atherosclerotic lesion from the media, expanding …
atherosclerosis. VSMCs invade the early atherosclerotic lesion from the media, expanding …
Vascular smooth muscle cells in atherosclerosis
GL Basatemur, HF Jørgensen, MCH Clarke… - Nature reviews …, 2019 - nature.com
Vascular smooth muscle cells (VSMCs) are a major cell type present at all stages of an
atherosclerotic plaque. According to the 'response to injury'and 'vulnerable …
atherosclerotic plaque. According to the 'response to injury'and 'vulnerable …
Olfactory receptor 2 in vascular macrophages drives atherosclerosis by NLRP3-dependent IL-1 production
M Orecchioni, K Kobiyama, H Winkels, Y Ghosheh… - Science, 2022 - science.org
Atherosclerosis is an inflammatory disease of the artery walls and involves immune cells
such as macrophages. Olfactory receptors (OLFRs) are G protein–coupled chemoreceptors …
such as macrophages. Olfactory receptors (OLFRs) are G protein–coupled chemoreceptors …
Stem cell pluripotency genes Klf4 and Oct4 regulate complex SMC phenotypic changes critical in late-stage atherosclerotic lesion pathogenesis
Background: Rupture and erosion of advanced atherosclerotic lesions with a resultant
myocardial infarction or stroke are the leading worldwide cause of death. However, we have …
myocardial infarction or stroke are the leading worldwide cause of death. However, we have …
Meta-analysis of leukocyte diversity in atherosclerotic mouse aortas
The diverse leukocyte infiltrate in atherosclerotic mouse aortas was recently analyzed in 9
single-cell RNA sequencing and 2 mass cytometry studies. In a comprehensive meta …
single-cell RNA sequencing and 2 mass cytometry studies. In a comprehensive meta …
Fate and state of vascular smooth muscle cells in atherosclerosis
Vascular smooth muscle cells (VSMCs) have long been associated with phenotypic
modulation/plasticity or dedifferentiation. Innovative technologies in cell lineage tracing …
modulation/plasticity or dedifferentiation. Innovative technologies in cell lineage tracing …
Macrophages in atherosclerosis regression
TJ Barrett - Arteriosclerosis, thrombosis, and vascular biology, 2020 - Am Heart Assoc
Macrophages play a central role in the development of atherosclerotic cardiovascular
disease (ASCVD), which encompasses coronary artery disease, peripheral artery disease …
disease (ASCVD), which encompasses coronary artery disease, peripheral artery disease …