Targeting angiogenesis in oncology, ophthalmology and beyond

Y Cao, R Langer, N Ferrara - Nature Reviews Drug Discovery, 2023 - nature.com
Angiogenesis is an essential process in normal development and in adult physiology, but
can be disrupted in numerous diseases. The concept of targeting angiogenesis for treating …

[HTML][HTML] Tumor heterogeneity reshapes the tumor microenvironment to influence drug resistance

A Zhang, K Miao, H Sun, CX Deng - International journal of …, 2022 - ncbi.nlm.nih.gov
Tumor heterogeneity is one of the hallmarks of cancer and a challenge in the field of
oncology. Tumor heterogeneity is the main cause of drug resistance, leading to therapeutic …

Molecular mechanism of VEGF and its role in pathological angiogenesis

A Ahmad, MI Nawaz - Journal of Cellular Biochemistry, 2022 - Wiley Online Library
Over the last seven decades, a significant scientific contribution took place in the delineation
of the implications of vascular endothelial‐derived growth factor (VEGF) in the processes of …

Strategies to reverse hypoxic tumor microenvironment for enhanced sonodynamic therapy

J Li, Z Yue, M Tang, W Wang, Y Sun… - Advanced Healthcare …, 2024 - Wiley Online Library
Sonodynamic therapy (SDT) has emerged as a highly effective modality for the treatment of
malignant tumors owing to its powerful penetration ability, noninvasiveness, site‐confined …

[HTML][HTML] Up-date on diabetic nephropathy

MC Pelle, M Provenzano, M Busutti, CV Porcu, I Zaffina… - Life, 2022 - mdpi.com
Diabetes is one of the leading causes of kidney disease. Diabetic kidney disease (DKD) is a
major cause of end-stage kidney disease (ESKD) worldwide, and it is linked to an increase …

[HTML][HTML] Inflammation balance in skeletal muscle damage and repair

H Tu, YL Li - Frontiers in immunology, 2023 - frontiersin.org
Responding to tissue injury, skeletal muscles undergo the tissue destruction and
reconstruction accompanied with inflammation. The immune system recognizes the …

Posterior reversible encephalopathy syndrome in patients with COVID-19

SC Parauda, V Gao, AN Gewirtz, NS Parikh… - Journal of the …, 2020 - Elsevier
Objective To report four patients with coronavirus disease 2019 (COVID-19) who developed
posterior reversible encephalopathy syndrome (PRES). Methods Patient data was …

Gestational hypoxia and developmental plasticity

CA Ducsay, R Goyal, WJ Pearce… - Physiological …, 2018 - journals.physiology.org
Hypoxia is one of the most common and severe challenges to the maintenance of
homeostasis. Oxygen sensing is a property of all tissues, and the response to hypoxia is …

Vascularization in tissue engineering: fundamentals and state-of-art

G Yang, B Mahadik, JY Choi… - Progress in Biomedical …, 2020 - iopscience.iop.org
Vascularization is among the top challenges that impede the clinical application of
engineered tissues. This challenge has spurred tremendous research endeavor, defined as …

[HTML][HTML] Differential but complementary HIF1α and HIF2α transcriptional regulation

NL Downes, N Laham-Karam, MU Kaikkonen… - Molecular Therapy, 2018 - cell.com
Effective vascular regeneration could provide therapeutic benefit for multiple pathologies,
especially in chronic peripheral artery disease (PAD) and myocardial ischemia. The hypoxia …