The modern pharmacology of paracetamol: therapeutic actions, mechanism of action, metabolism, toxicity and recent pharmacological findings
Paracetamol is used worldwide for its analgesic and antipyretic actions. It has a spectrum of
action similar to that of NSAIDs and resembles particularly the COX-2 selective inhibitors …
action similar to that of NSAIDs and resembles particularly the COX-2 selective inhibitors …
Dynamics of arachidonic acid mobilization by inflammatory cells
AM Astudillo, D Balgoma, MA Balboa… - Biochimica et Biophysica …, 2012 - Elsevier
The development of mass spectrometry-based techniques is opening new insights into the
understanding of arachidonic acid (AA) metabolism. AA incorporation, remodeling and …
understanding of arachidonic acid (AA) metabolism. AA incorporation, remodeling and …
Secreted phospholipase A2 revisited
M Murakami, Y Taketomi, H Sato… - The journal of …, 2011 - academic.oup.com
Abstract Phospholipase A2 (PLA2) catalyses the hydrolysis of the sn-2 position of
glycerophospholipids to yield fatty acids and lysophospholipids. So far, more than 30 …
glycerophospholipids to yield fatty acids and lysophospholipids. So far, more than 30 …
[HTML][HTML] The interaction of secreted phospholipase A2-IIA with the microbiota alters its lipidome and promotes inflammation
E Doré, C Joly-Beauparlant, S Morozumi, A Mathieu… - JCI insight, 2022 - ncbi.nlm.nih.gov
Abstract Secreted phospholipase A 2-IIA (sPLA 2-IIA) hydrolyzes phospholipids to liberate
lysophospholipids and fatty acids. Given its poor activity toward eukaryotic cell membranes …
lysophospholipids and fatty acids. Given its poor activity toward eukaryotic cell membranes …
Antibody-induced pain-like behavior and bone erosion: links to subclinical inflammation, osteoclast activity, and acid-sensing ion channel 3–dependent sensitization
A Jurczak, L Delay, J Barbier, N Simon, E Krock… - Pain, 2022 - journals.lww.com
Several bone conditions, eg, bone cancer, osteoporosis, and rheumatoid arthritis (RA), are
associated with a risk of developing persistent pain. Increased osteoclast activity is often the …
associated with a risk of developing persistent pain. Increased osteoclast activity is often the …
Roles of secreted phospholipase A2 group IIA in inflammation and host defense
E Dore, E Boilard - Biochimica et Biophysica Acta (BBA)-Molecular and …, 2019 - Elsevier
Among all members of the secreted phospholipase A 2 (sPLA 2) family, group IIA sPLA 2
(sPLA 2-IIA) is possibly the most studied enzyme. Since its discovery, many names have …
(sPLA 2-IIA) is possibly the most studied enzyme. Since its discovery, many names have …
Phospholipases of mineralization competent cells and matrix vesicles: roles in physiological and pathological mineralizations
The present review aims to systematically and critically analyze the current knowledge on
phospholipases and their role in physiological and pathological mineralization undertaken …
phospholipases and their role in physiological and pathological mineralization undertaken …
Structural and Functional Aspects of Targeting the Secreted Human Group IIA Phospholipase A2
RR Kim, Z Chen, T J. Mann, K Bastard, K F. Scott… - Molecules, 2020 - mdpi.com
Human group IIA secretory phospholipase A2 (hGIIA) promotes the proliferation of cancer
cells, making it a compelling therapeutic target, but it is also significant in other inflammatory …
cells, making it a compelling therapeutic target, but it is also significant in other inflammatory …
Critical Role of TLR2 and MyD88 for Functional Response of Macrophages to a Group IIA-Secreted Phospholipase A2 from Snake Venom
E Leiguez, KC Giannotti, V Moreira, MH Matsubara… - PLoS …, 2014 - journals.plos.org
The snake venom MT-III is a group IIA secreted phospholipase A2 (sPLA2) enzyme with
functional and structural similarities with mammalian pro-inflammatory sPLA2s of the same …
functional and structural similarities with mammalian pro-inflammatory sPLA2s of the same …
Respective contribution of cytosolic phospholipase A2α and secreted phospholipase A2 IIA to inflammation and eicosanoid production in arthritis
AC Duchez, LH Boudreau, GS Naika… - Prostaglandins & Other …, 2019 - Elsevier
Abstract Phospholipase A 2 s (PLA 2) play a key role in generation of eicosanoids. Cytosolic
PLA 2 α (cPLA 2 α) is constitutively expressed in most cells, whereas IIA secreted PLA 2 …
PLA 2 α (cPLA 2 α) is constitutively expressed in most cells, whereas IIA secreted PLA 2 …