Engineered organoids for biomedical applications

NR de Barros, C Wang, S Maity, A Peirsman… - Advanced Drug Delivery …, 2023 - Elsevier
As miniaturized and simplified stem cell-derived 3D organ-like structures, organoids are
rapidly emerging as powerful tools for biomedical applications. With their potential for …

Present application and perspectives of organoid imaging technology

K Fei, J Zhang, J Yuan, P Xiao - Bioengineering, 2022 - mdpi.com
An organoid is a miniaturized and simplified in vitro model with a similar structure and
function to a real organ. In recent years, the use of organoids has increased explosively in …

Organoid imaging: seeing development and function

R Keshara, YH Kim… - Annual review of cell and …, 2022 - annualreviews.org
Organoids are miniaturized and simplified versions of an organ produced in vitro from stem
or progenitor cells. They are used as a model system consisting of multiple cell types …

Advanced 3D imaging and organoid bioprinting for biomedical research and therapeutic applications

S Maharjan, C Ma, B Singh, H Kang, G Orive… - Advanced Drug Delivery …, 2024 - Elsevier
Organoid cultures offer a valuable platform for studying organ-level biology, allowing for a
closer mimicry of human physiology compared to traditional two-dimensional cell culture …

Human brain organoids-on-chip: Advances, challenges, and perspectives for preclinical applications

H Castiglione, PA Vigneron, C Baquerre, F Yates… - Pharmaceutics, 2022 - mdpi.com
There is an urgent need for predictive in vitro models to improve disease modeling and drug
target identification and validation, especially for neurological disorders. Cerebral …

Recent advances in brain organoid technology for human brain research

E Jeong, S Choi, SW Cho - ACS Applied Materials & Interfaces, 2022 - ACS Publications
Brain organoids are self-assembled three-dimensional aggregates with brain-like cell types
and structures and have emerged as new model systems that can be used to investigate …

Imaging three-dimensional brain organoid architecture from meso-to nanoscale across development

JE Rodriguez-Gatica, V Iefremova… - …, 2022 - journals.biologists.com
Organoids are stem cell-derived three-dimensional cultures offering a new avenue to model
human development and disease. Brain organoids allow the study of various aspects of …

In-silico and in-vitro morphometric analysis of intestinal organoids

S Montes-Olivas, D Legge, A Lund… - PLoS Computational …, 2023 - journals.plos.org
Organoids offer a powerful model to study cellular self-organisation, the growth of specific
tissue morphologies in-vitro, and to assess potential medical therapies. However, the …

Mu-Net a Light Architecture for Small Dataset Segmentation of Brain Organoid Bright-Field Images

C Brémond Martin, C Simon Chane, C Clouchoux… - Biomedicines, 2023 - mdpi.com
To characterize the growth of brain organoids (BOs), cultures that replicate some early
physiological or pathological developments of the human brain are usually manually …

Correlation Clustering of Organoid Images

J Presberger, R Keshara, D Stein, YH Kim… - arXiv preprint arXiv …, 2024 - arxiv.org
In biological and medical research, scientists now routinely acquire microscopy images of
hundreds of morphologically heterogeneous organoids and are then faced with the task of …