Frailty in aging marks a state of decreased reserves resulting in increased vulnerability to
adverse outcomes when exposed to stressors. This Perspective synthesizes the evidence …

For the last five decades, science has managed to delineate the mechanisms by which
stress hormones can impact on the human brain. Receptors for glucocorticoids are found in …

The WHO World report on ageing and health is not for the book shelf it is a living breathing
testament to all older people who have fought for their voice to be heard at all levels of …

Background Inequalities in health are acknowledged in many developed countries, whereby
disadvantaged groups systematically suffer from worse health outcomes such as lower life …

Stress is a state of the mind, involving both brain and body as well as their interactions; it
differs among individuals and reflects not only major life events but also the conflicts and …

The brain is the central organ for adaptation to experiences, including stressors, which are
capable of changing brain architecture as well as altering systemic function through …

There is an urgent need to identify lifestyle activities that reduce functional decline and
dementia associated with population aging. The goals of this article are to review critically …

Background Volunteering has been advocated by the United Nations, and American and
European governments as a way to engage people in their local communities and improve …

As the central organ of stress and adaptation to stressors, the brain plays a pivotal role in
behavioral and physiological responses that may lead to successful adaptation or to …

The brain is the key organ of stress reactivity, coping, and recovery processes. Within the
brain, a distributed neural circuitry determines what is threatening and thus stressful to the …