The midcycle surge of LH sets in motion interconnected networks of signaling cascades to
bring about rupture of the follicle and release of the oocyte during ovulation. Many mediators …

Cancer genomic, transcriptomic, and proteomic profiling has generated extensive data that
necessitate the development of tools for its analysis and dissemination. We developed …

Prostate cancer is a highly prevalent form of cancer that is usually slow-developing and
benign. Due to its high prevalence, it is, however, still the second most common cause of …

Unlike several other tumor types, prostate cancer rarely responds to immune checkpoint
blockade (ICB). To define tumor cell intrinsic factors that contribute to prostate cancer …

Oxidative stress, inflammation and androgen receptor (AR) signaling play a pivotal role in
the initiation, development and progression of prostate cancer (PCa). Numerous papers in …

Transcription factors (TFs) activate enhancers to drive cell-specific gene programs in
response to signals, but our understanding of enhancer assembly during signaling events is …

Abstract Background Sirtuin-7 (SIRT7) is associated with the maintenance of tumorigenesis.
However, its functional roles and oncogenic mechanisms in prostate cancer (PCa) are …

Preeclampsia is one of the three leading causes of maternal morbidity and mortality
worldwide. It afflicts 2–8% of pregnancies and is the most common cause of gestational …

Chronic inflammation is one of the definite factors leading to the occurrence and
development of tumors, including prostate cancer (PCa). The androgen receptor (AR) …

Aging markedly increases cancer risk, yet our mechanistic understanding of how aging
influences cancer initiation is limited. Here we demonstrate that the loss of ZNRF3, an …