Simple Summary The IL-12 family cytokines play an important role in regulating the tumor
immune contexture. Recent efforts geared towards the development of better immune …

Signal transducers and activators of transcription (STATs) comprise a family of cytoplasmic
transcription factors that mediate intracellular signaling that is usually generated at cell …

Chronic mucocutaneous candidiasis disease (CMCD) may be caused by autosomal
dominant (AD) IL-17F deficiency or autosomal recessive (AR) IL-17RA deficiency. Here …

Since their establishment thirty years ago, THP-1 cells have become one of most widely
used cell lines to investigate the function and regulation of monocytes and macrophages in …

Inborn errors of human IL-17 immunity underlie chronic mucoc... : Current Opinion in Allergy and
Clinical Immunology Inborn errors of human IL-17 immunity underlie chronic mucocutaneous …

Proteins of the signal transducer and activator of transcription (STAT) family mediate cellular
responses to cytokines and growth factors. Aberrant regulation of the STAT3 oncogene …

The role of the immune system in anti-tumor immunity cannot be overstated, as it holds the
potential to promote tumor eradication or prevent tumor cell escape. Cytokines are critical to …

Mice with defective IL‐17 immunity display a broad vulnerability to various infectious agents
at diverse mucocutaneous surfaces. In humans, the study of patients with various primary …

Cytokines are important molecules that regulate the ontogeny and function of the immune
system. They are small secreted proteins usually produced upon activation of cells of the …

Among a wide range of cytokines, the Interleukin 12 (IL-12) family has its unique structural,
functional, and immunological characteristics that have made this family as important …