Progress in the field of precision medicine has changed the landscape of cancer therapy.
Precision medicine is propelled by technologies that enable molecular profiling, genomic …

Advanced drug delivery systems (DDS) enhance treatment efficacy of different therapeutics
in a dosage, spatial, and/or temporal controlled manner. To date, numerous chemical-or …

Vascular endothelium offers a variety of therapeutic targets for the treatment of cancer,
cardiovascular diseases, inflammation, and oxidative stress. Significant research has been …

Oligonucleotide-based agents have the potential to treat or cure almost any disease, and
are one of the key therapeutic drug classes of the future. Bioconjugated oligonucleotides, a …

Extravasation is the first step for nanomedicines in circulation to reach targeted solid tumors.
Traditional nanomedicines have been designed to extravasate into tumor interstitium …

Nanoparticles are commonly administered through systemic injection, which exposes them
to the dynamic environment of the bloodstream. Injected nanoparticles travel within the …

It is increasingly apparent that bacteriophages, viruses that infect bacteria and more
commonly referred to as simply phages, have tropisms outside their bacterial hosts. Using …

Endothelial cells play critical roles in circulatory homeostasis and are also the gateway to
the major organs of the body. Dysfunction, injury, and gene expression profiles of these cells …

Ex vivo normothermic machine perfusion (NMP) is a new clinical strategy to assess and
resuscitate organs likely to be declined for transplantation, thereby increasing the number of …

The bloodstream is the main transporting pathway for drug delivery systems (DDS) from the
site of administration to the intended site of action. In many cases, components of the …