The neurobiology of SARS-CoV-2 infection

J Meinhardt, S Streit, C Dittmayer, RV Manitius… - Nature Reviews …, 2024 - nature.com
Worldwide, over 694 million people have been infected with SARS-CoV-2, with an estimated
55–60% of those infected developing COVID-19. Since the beginning of the pandemic in …

The role of microglia in viral encephalitis: a review

Z Chen, D Zhong, G Li - Journal of neuroinflammation, 2019 - Springer
Viral encephalitis is still very prominent around the world, and traditional antiviral therapies
still have shortcomings. Some patients cannot get effective relief or suffer from serious …

Dysregulation of brain and choroid plexus cell types in severe COVID-19

AC Yang, F Kern, PM Losada, MR Agam, CA Maat… - Nature, 2021 - nature.com
Although SARS-CoV-2 primarily targets the respiratory system, patients with and survivors of
COVID-19 can suffer neurological symptoms,–. However, an unbiased understanding of the …

Neuropathology of patients with COVID-19 in Germany: a post-mortem case series

J Matschke, M Lütgehetmann, C Hagel… - The Lancet …, 2020 - thelancet.com
Background Prominent clinical symptoms of COVID-19 include CNS manifestations.
However, it is unclear whether severe acute respiratory syndrome coronavirus 2 (SARS-CoV …

COVID-19 neuropathology at columbia university irving medical center/New York presbyterian hospital

KT Thakur, EH Miller, MD Glendinning, O Al-Dalahmah… - Brain, 2021 - academic.oup.com
Many patients with SARS-CoV-2 infection develop neurological signs and symptoms;
although, to date, little evidence exists that primary infection of the brain is a significant …

Acute and non-resolving inflammation associate with oxidative injury after human spinal cord injury

T Zrzavy, C Schwaiger, I Wimmer, T Berger, J Bauer… - Brain, 2021 - academic.oup.com
Traumatic spinal cord injury is a devastating insult followed by progressive cord atrophy and
neurodegeneration. Dysregulated or non-resolving inflammatory processes can disturb …

COVID‐19‐related neuropathology and microglial activation in elderly with and without dementia

TE Poloni, V Medici, M Moretti, SD Visonà… - Brain …, 2021 - Wiley Online Library
The actual role of SARS‐CoV‐2 in brain damage remains controversial due to lack of
matched controls. We aim to highlight to what extent is neuropathology determined by SARS …

[HTML][HTML] Deep spatial profiling of human COVID-19 brains reveals neuroinflammation with distinct microanatomical microglia-T-cell interactions

M Schwabenland, H Salié, J Tanevski, S Killmer… - Immunity, 2021 - cell.com
COVID-19 can cause severe neurological symptoms, but the underlying pathophysiological
mechanisms are unclear. Here, we interrogated the brain stems and olfactory bulbs in …

The role of microglia in neuroinflammation of the spinal cord after peripheral nerve injury

TS Pottorf, TM Rotterman, WM McCallum… - Cells, 2022 - mdpi.com
Peripheral nerve injuries induce a pronounced immune reaction within the spinal cord,
largely governed by microglia activation in both the dorsal and ventral horns. The …

Recapitulation of pathophysiological features of AD in SARS-CoV-2-infected subjects

E Griggs, K Trageser, S Naughton, EJ Yang, B Mathew… - Elife, 2023 - elifesciences.org
Infection with the etiological agent of COVID-19, SARS-CoV-2, appears capable of
impacting cognition in some patients with post-acute sequelae of SARS-CoV-2 (PASC). To …