[HTML][HTML] A comprehensive review on pharmacological applications and drug-induced toxicity of valproic acid

A Safdar, F Ismail - Saudi Pharmaceutical Journal, 2023 - Elsevier
Valproic acid, a branching short chain fatty acid, is a popular drug to treat epilepsy and acts
as a mood-stabilizing drug. The obstruction of ion channels and Gamma Amino Butyrate …

Bitter gourd (Momordica charantia) possess developmental toxicity as revealed by screening the seeds and fruit extracts in zebrafish embryos

MF Khan, N Abutaha, FA Nasr, AS Alqahtani… - … and alternative medicine, 2019 - Springer
Abstract Background Bitter gourd (Momordica charantia) has attracted the focus of
researchers owing to its excellent anti-diabetic action. The beneficial effect of Momordica …

[HTML][HTML] Phyllanthus emblica leaf extract ameliorates testicular damage in rats with chronic stress

S Arun, J Burawat, S Yannasithinon… - Journal of Zhejiang …, 2018 - ncbi.nlm.nih.gov
Stress affects the male reproductive system and can cause sub-fertility or infertility. Although
Phyllanthus emblica L.(PE) extract has been shown to have high antioxidant capacity and …

The effects of edaravone, a free‐radical scavenger in lung injury induced by valproic acid demonstrated via different biochemical parameters

BB Bayrak, S Yilmaz… - … of Biochemical and …, 2021 - Wiley Online Library
In this study, we aimed to evaluate whether edaravone (EDA) has a protective role against
valproic acid (VPA)‐induced lung damage via its antioxidative activity. Male Sprague …

Evaluation of antioxidant capacity and reproductive toxicity of aqueous extract of Thai Mucuna pruriens seeds

S Iamsaard, S Arun, J Burawat, S Yannasithinon… - Journal of Integrative …, 2020 - Elsevier
Objective In traditional medicine, the seeds of Thai Mucuna pruriens (T-MP) are used to treat
male dysuria and are believed to enhance fertility. However, information pertaining to the …

[PDF][PDF] Protective effect of edaravone on rat testis after valproic acid treatment

Ç Çelik, BB Bayrak… - Journal of Research …, 2022 - researchgate.net
Valproic acid (n-dipropyl-acetic acid, VPA) is a medication used as anticonvulsant in the
treatment of bipolar disorder, and for migraine prophylaxis. Long-term use of VPA is known …

The effect of Dolichandrone serrulata (wall. ex DC.) Seem. flower extract containing antioxidant capacity and terpenoids on the male reproductive system

C Chaimontri, S Arun, T Sawatpanich… - Andrologia, 2021 - Wiley Online Library
Although the fruit extract of Dolichandrone genus was shown to inhibit spermatogenesis, the
reproductive toxicity of Dolichandrone serrulata flowers (DSFs) is not documented. Recent …

Valproic acid changes the expression of tyrosine‐phosphorylated proteins in rat seminal vesicle

S Tongpan, W Sukhorum, S Arun, T Sawatphanich… - Andrologia, 2019 - Wiley Online Library
Previous studies reported the effects of valproic acid (VPA) on tyrosine‐phosphorylated
(TyrPho) protein expression in the testis and epididymis, but its effects on that in the seminal …

Ameliorative effects of Edaravone against Valproic Acid-Induced kidney damage

BB Bayrak, S Sancar, NH Cakmak, S Bolkent… - Journal of Molecular …, 2025 - Springer
Valproic acid (VPA) is a well-known and increasingly documented antiepileptic drug that has
been widely used in the treatment of epilepsy and/or epilepsy-related disorders. Prolonged …

Momordica charantia fruit extract with antioxidant capacity improves the expression of tyrosine-phosphorylated proteins in epididymal fluid of chronic stress rats

S Arun, T Kamollerd, N Tangsrisakda… - Journal of integrative …, 2022 - Elsevier
Objective Although the protective effects of Momordica charantia L.(MC) extract on chemical-
induced testicular damage have been studied, the preventive effects of MC extract on …