Lipids, as the basic component of cell membranes, play an important role in human health
as well as brain function. The brain is highly enriched in lipids, and disruption of lipid …

As requested by the editors of this special issue of Hippocampus on Scientific Histories of
Hippocampal Research, this review provides a detailed personal perspective and historical …

Immunotherapeutic strategies to combat neurodegenerative disorders have galvanized the
scientific community since the first dramatic successes in mouse models recreating aspects …

As populations age, prevalence of Alzheimer's disease (AD) is rising. Over 100 years of
research has provided valuable insights into the pathophysiology of the disease, for which …

CREB binding protein (CBP) is a transcriptional coactivator with histone acetyltransferase
activity. Our prior study suggested that CBP might be a key target of presenilins in the …

There has been a long-standing need to develop efficient and standardized behavioral test
methods for evaluating higher-order brain functions in mice. Here, we developed and …

Aged canines (dogs) accumulate human-type β-amyloid (Aβ) in diffuse plaques in the brain
with parallel declines in cognitive function. We hypothesized that reducing Aβ in a …

Background The development of a safe and effective AD vaccine requires a delicate
balance between providing an adequate anti-Aβ antibody response sufficient to provide …

Alzheimer's disease is associated with a dramatic decline in cognitive performance
including hippocampal‐dependent memory. We have investigated one feature of …

Abnormalities in hippocampal structure and function are characteristics of early Alzheimer's
disease (AD). Behavioral tests measuring hippocampal-dependent memory in rodents are …