Clinical history, questionnaire data and response to antisecretory therapy are insufficient to
make a conclusive diagnosis of GERD in isolation, but are of value in determining need for …

GERD is a common condition worldwide. Key mechanisms of disease include abnormal
oesophagogastric junction structure and function, and impaired oesophageal clearance. A …

1 ESGE recommends that, where there is a suspicion of eosinophilic esophagitis, at least six
biopsies should be taken, two to four biopsies from the distal esophagus and two to four …

OBJECTIVES A globally acceptable definition and classification of gastroesophageal reflux
disease (GERD) is desirable for research and clinical practice. The aim of this initiative was …

Background Gastroesophageal reflux disease (GERD) is one of the most frequent benign
disorders of the upper gastrointestinal tract. Management of GERD has always been …

BACKGROUND & AIMS: Gastroesophageal reflux causes inflammation and intestinal
metaplasia and its downstream sequelum adenocarcinoma in the distal esophagus. The …

OBJECTIVES: We sought to develop an international consensus on the definition of
gastroesophageal reflux disease (GERD) in the pediatric population. METHODS: Using the …

BACKGROUND & AIMS: Reflux esophagitis is believed to be caused by the caustic effects of
refluxed gastric acid on esophageal epithelial cells. However, caustic chemical injuries …

Background Recently, it has been suggested that low esophageal basal impedance may
reflect impaired mucosal integrity and increased acid sensitivity. We aimed to compare …

Traditional views of nutritional carcinogenesis depend on the identification of exogenous
carcinogens as major risk factors. As our understanding evolves, it is clear that the pattern of …