Toxicokinetics of β-amanitin in mice and in vitro drug–drug interaction potential
The toxicokinetics of β-amanitin, a toxic bicyclic octapeptide present abundantly in
Amanitaceae mushrooms, was evaluated in mice after intravenous (iv) and oral …
Amanitaceae mushrooms, was evaluated in mice after intravenous (iv) and oral …
Dysregulations of UDP-glucuronosyltransferases in rats with valproic acid and high fat diet induced fatty liver
L Zhang, X Chu, H Wang, H Xie, C Guo, L Cao… - European journal of …, 2013 - Elsevier
Both high fat diet (HFD) and valproic acid (VPA) interfere with mitochondrial β-oxidation of
fatty acids, which subsequently triggers microvesicular fatty liver and hepatic dysfunction …
fatty acids, which subsequently triggers microvesicular fatty liver and hepatic dysfunction …
UGT1A1 haplotype mutation among Asians in Singapore
YY Zhou, LY Lee, SY Ng, CPP Hia, KT Low, YS Chong… - Neonatology, 2009 - karger.com
Background: The uridine diphosphate glucuronosyltransferase 1A1 (UGT1A1) enzyme is
responsible for conjugation of the bilirubin in the liver as well as for drug metabolism. Some …
responsible for conjugation of the bilirubin in the liver as well as for drug metabolism. Some …
Electrochemical sensor highly selective for estradiol valerate determination based on a modified carbon paste with iron tetrapyridinoporphyrazine
IV Batista, MRV Lanza, ILT Dias, SMCN Tanaka… - Analyst, 2008 - pubs.rsc.org
This work reports the use of iron tetrapyridinoporphyrazine (FeTPyPz) as a highly selective
catalyst in the construction of an electrochemical sensor for estradiol valerate (EV) …
catalyst in the construction of an electrochemical sensor for estradiol valerate (EV) …
Stereoselective metabolism of racemic carvedilol by UGT1A1 and UGT2B7, and effects of mutation of these enzymes on glucuronidation activity
Y Takekuma, T Takenaka, K Yamazaki… - Biological and …, 2007 - jstage.jst.go.jp
Carvedilol, an a-and b-adrenergic blocking drug, is mainly metabolized by CYP2D6,
UGT1A1, UGT2B4 and UGT2B7. This drug is administered orally as a racemic mixture of R …
UGT1A1, UGT2B4 and UGT2B7. This drug is administered orally as a racemic mixture of R …
Comprehensive Analysis of UGT1A1 Genetic Polymorphisms in Chinese Tibetan and Han Populations
X Zhang, X Meng, Y Wang, W Yan, J Yang - Biochemical genetics, 2012 - Springer
The study of polymorphism of the UGT1A1 gene has not been reported in the Chinese
Tibetan population, and there are no comparisons of genetic polymorphism in the gene …
Tibetan population, and there are no comparisons of genetic polymorphism in the gene …
Establishment of the experimental procedure for prediction of conjugation capacity in mutant UGT1A1
Y Takaoka, A Takeuchi, A Sugano, K Miura, M Ohta… - Plos one, 2019 - journals.plos.org
UDP-glucuronosyltransferase 1A1 (UGT1A1) is an enzyme that is found in the endoplasmic
reticulum membrane and can reportedly have a large number of amino acid substitutions …
reticulum membrane and can reportedly have a large number of amino acid substitutions …
Effect of the genetic mutant G71R in uridine diphosphate-glucuronosyltransferase 1A1 on the conjugation of bilirubin
H Chen, D Zhong, Z Gao, X Wu - Open Life Sciences, 2022 - degruyter.com
We aimed to investigate the effect of the genetic mutant G71R (c. 211G> A) in uridine
diphosphate (UDP)-glucuronosyltransferase 1A1 (UGT1A1) on the glucuronidation of …
diphosphate (UDP)-glucuronosyltransferase 1A1 (UGT1A1) on the glucuronidation of …
The measurement of estrogens
G Holder, HLJ Makin, HL Bradlow - Steroid Analysis, 2010 - Springer
Biologists use the word 'estrogen'when referring to molecules which have the ability to
induce uterine growth or vaginal cornification in the immature or ovariectomized rodent. The …
induce uterine growth or vaginal cornification in the immature or ovariectomized rodent. The …