M Komatsu, T Inada, NN Noda - Molecular Cell, 2024 - cell.com
Summary Ubiquitin-fold modifier 1 (UFM1) is a ubiquitin-like protein covalently conjugated with intracellular proteins through UFMylation, a process similar to ubiquitylation. Growing …
F Scavone, SC Gumbin… - Proceedings of the …, 2023 - National Acad Sciences
Ribosomes that stall while translating cytosolic proteins are incapacitated by incomplete nascent chains, termed “arrest peptides”(APs) that are destroyed by the ubiquitin …
Ribosomes that become stalled on truncated or damaged mRNAs during protein synthesis must be rescued for the cell to survive. Bacteria have evolved a diverse array of rescue …
P Tesina, S Ebine, R Buschauer, M Thoms, Y Matsuo… - Molecular Cell, 2023 - cell.com
Ribosome-associated quality control (RQC) is a conserved process degrading potentially toxic truncated nascent peptides whose malfunction underlies neurodegeneration and …
MCJ Yip, S Shao - Trends in biochemical sciences, 2021 - cell.com
Ribosomes that stall inappropriately during protein synthesis harbor proteotoxic components linked to cellular stress and neurodegenerative diseases. Molecular mechanisms that …
R Endo, YK Chen, J Burke… - Proceedings of the …, 2023 - National Acad Sciences
Ribosome-associated quality control (RQC) pathway is responsible for degradation of nascent polypeptides in aberrantly stalled ribosomes, and its defects may lead to …
J Park, J Lee, J Kim, J Lee, H Park… - Nucleic Acids …, 2021 - academic.oup.com
C9ORF72-derived dipeptide repeat proteins have emerged as the pathogenic cause of neurodegeneration in amyotrophic lateral sclerosis and frontotemporal dementia (C9 …
In ribosome-associated quality control (RQC), nascent polypeptides produced by interrupted translation are modified with C-terminal polyalanine tails (" Ala-tails") that function outside …
Stalling of ribosomes engaged in protein synthesis can lead to significant defects in the function of newly synthesized proteins and thereby impair protein homeostasis …