Ribosome-associated quality-control (RQC) surveys incomplete nascent polypeptides
produced by interrupted translation. Central players in RQC are the human ribosome-and …

Summary Ubiquitin-fold modifier 1 (UFM1) is a ubiquitin-like protein covalently conjugated
with intracellular proteins through UFMylation, a process similar to ubiquitylation. Growing …

Ribosomes that stall while translating cytosolic proteins are incapacitated by incomplete
nascent chains, termed “arrest peptides”(APs) that are destroyed by the ubiquitin …

Ribosomes that become stalled on truncated or damaged mRNAs during protein synthesis
must be rescued for the cell to survive. Bacteria have evolved a diverse array of rescue …

Ribosome-associated quality control (RQC) is a conserved process degrading potentially
toxic truncated nascent peptides whose malfunction underlies neurodegeneration and …

Ribosomes that stall inappropriately during protein synthesis harbor proteotoxic components
linked to cellular stress and neurodegenerative diseases. Molecular mechanisms that …

Ribosome-associated quality control (RQC) pathway is responsible for degradation of
nascent polypeptides in aberrantly stalled ribosomes, and its defects may lead to …

C9ORF72-derived dipeptide repeat proteins have emerged as the pathogenic cause of
neurodegeneration in amyotrophic lateral sclerosis and frontotemporal dementia (C9 …

In ribosome-associated quality control (RQC), nascent polypeptides produced by interrupted
translation are modified with C-terminal polyalanine tails (" Ala-tails") that function outside …

Stalling of ribosomes engaged in protein synthesis can lead to significant defects in the
function of newly synthesized proteins and thereby impair protein homeostasis …