Mammalian eggs (oocytes) are formed during fetal life and establish associations with
somatic cells to form primordial follicles that create a store of germ cells (the primordial pool) …

Across the Western World there is an increasing trend to postpone childbearing.
Consequently, the negative influence of age on oocyte quality may lead to a difficulty in …

Introgression of farmed salmon escapees into wild stocks is a major threat to the genetic
integrity of wild populations. Using germ cell-free fish in aquaculture may mitigate this …

We describe here the isolation of cDNA and genomic clones corresponding to the mouse
gene encoding anti-Müllerian hormone, and the use of these clones as molecular probes to …

The pivotal point of vertebrate sex determination is the development of the gonad into a
testis or ovary, which governs phenotypic sex through the production of hormones. The …

Ovarian reserve is determined by the number of primordial follicles in the ovary. Quiescent
primordial follicles are activated for growth and pass through stages of development before …

As complete absence of germ cells leads to sterile males in zebrafish, we explored the
relationship between primordial germ cell (PGC) number and sexual development. Our …

To further elucidate the roles of germ cells in the sex differentiation of gonads, we have used
the medaka, a teleost fish, to generate mutants that lack germ cells from the onset of …

A prerequisite to the understanding of the ovarian diseases and infertility is a thorough
understanding of normal embryology and physiology of the ovary. Therefore, the objective of …

A critical element of successful sexual reproduction is the generation of sexually dimorphic
adult reproductive organs, the testis and ovary, which produce functional gametes …