Chemoresistance and metastasis are the major challenges for the current ovarian cancer
treatment. Understanding the mechanisms of ovarian cancer progression and metastasis is …

The spread of cancer cells to distant organs represents a major clinical challenge in the
treatment of cancer. Epithelial–mesenchymal transition (EMT) has emerged as a key …

Metastasis is the leading reason for the resultant mortality of patients with cancer. The past
few decades have witnessed remarkable progress in understanding the molecular and …

Background Ovarian cancer is the most lethal gynecologic cancer and the fifth leading
cause of cancer-related mortality in women worldwide. Despite various attempts to improve …

Abstract Epithelial-mesenchymal transition (EMT), a biological process by which polarized
epithelial cells convert into a mesenchymal phenotype, has been implicated to contribute to …

OBJECTIVES: MUC16 (CA125) protein is a high molecular weight mucin overexpressed in
the majority of epithelial ovarian cancers (EOC) but not in the epithelium of normal ovaries …

Purpose: Mucin expression is a common feature of most adenocarcinomas and features
prominently in current attempts to improve diagnosis and therapy for pancreatic cancer and …

The fluorinated analog of deoxycytidine, Gemcitabine (Gemzar), is the main
chemotherapeutic drug in pancreatic cancer, but survival remains weak mainly because of …

Ovarian cancer is the most lethal gynecologic malignancy, with the majority of patients dying
within 5 years of diagnosis. This poor survival of patients diagnosed with this malignancy is …

MUC16/CA125 is a tumor marker currently used in clinics for the follow-up of patients with
ovarian cancer. However, MUC16 expression is not entirely restricted to ovarian …